本文選題：人類免疫缺陷病毒 + gp��； 參考：《醫(yī)學(xué)研究生學(xué)報(bào)》2015年08期

【摘要】：人類免疫缺陷病毒(human immunodeficiency virus,HIV)相關(guān)的感覺神經(jīng)病變(HIV-related sensory neuropathy,HIV-SN)主要包含HIV感染引起的遠(yuǎn)端感覺多神經(jīng)病變(distal sensory polyneuropathy,DSP)和抗逆轉(zhuǎn)錄病毒毒性神經(jīng)病變(antiretroviral toxic neuropathies,ATN)。文中主要闡述了HIV-DSP可能與gp120誘導(dǎo)產(chǎn)生的促炎細(xì)胞因子、趨化因子、活性氧及P物質(zhì)有關(guān),而HIV-ATN則可能與應(yīng)用dd C等抗逆轉(zhuǎn)錄病毒藥物引發(fā)的線粒體毒性及小膠質(zhì)細(xì)胞增生有關(guān),并且與HIVDSP的分子機(jī)制類似,這意味著目前治療艾滋病的常規(guī)方法可能會(huì)進(jìn)一步加重患者的神經(jīng)病理性疼痛。因此,開展HIV相關(guān)神經(jīng)病理性疼痛的神經(jīng)化學(xué)和藥理機(jī)制的研究,將為其新型有效治療藥物提供新的作用靶點(diǎn)。
[Abstract]:HIV-related sensory neuropathysises (HIV-SNNs) mainly include distal sensory neuropathytic DSPs caused by HIV infection and antiviral toxic neuropathies ATNs. This paper mainly discusses that HIV-DSP may be related to pro-inflammatory cytokines, chemokines, reactive oxygen species and substance P induced by gp120, while HIV-ATN may be related to mitochondrial toxicity and microglial proliferation induced by ddc and other antiretrovirals. And similar to the molecular mechanism of HIVDSP, this means that the current routine treatment of AIDS may further aggravate neuropathic pain in patients. Therefore, the research on the neurochemical and pharmacological mechanism of neuropathic pain associated with HIV will provide a new target for new and effective drugs for the treatment of neuropathic pain.
【作者單位】： 南昌大學(xué)基礎(chǔ)醫(yī)學(xué)院生理學(xué)教研室;
【基金】：國家自然科學(xué)基金(81260187) 江西省教育廳科學(xué)技術(shù)研究項(xiàng)目(GJJ14146) 江西省青年科學(xué)基金(20114 BAB215022) 江西省研究生創(chuàng)新專項(xiàng)資金項(xiàng)目(YC2014-S098)
【分類號(hào)】：R512.91
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本文編號(hào)：1876091