本文選題：HAART維持治療 + 脫失　； 參考：《中國健康教育》2015年12期

【摘要】：目的掌握云南省德宏州2004—2013年間HIV感染者高效抗逆轉(zhuǎn)錄病毒治療的保持率及其影響因素。方法以開始抗病毒治療時間作為進入隊列的時間進行動態(tài)隊列研究,計算不同隨訪時間HAART保持率,運用Cox比例風(fēng)險回歸模型分析可能的影響因素。結(jié)果 2004—2013年間共7580人入組治療,入組者國籍以中國籍為多,占84.1%;五縣市中以盈江縣入組人數(shù)最多,為26.3%;入組者以男性為主,占62.2%;入組平均年齡(36.9±10.0)歲,以26~35歲為主;婚姻狀況以已婚為主,占70.9%;HIV感染途徑以性傳播為主,占68.3%;基線CD4+T淋巴細(xì)胞計數(shù)以≤200者居多,占42.5%;入組成員的初始治療方案中主要以齊多夫定(AZT)為主的治療方案占據(jù)比例最大,為44.0%。截至觀察期末,入組治療后1~9年的累積保持率分別為92.2%、87.7%、85.3%、83.8%、81.8%、80.1%、78.5%、76.8%和73.8%。Cox比例風(fēng)險模型多因素結(jié)果顯示,研究對象國籍、所在治療點、性別、婚姻狀況、HIV感染途徑、基線CD4+T淋巴細(xì)胞計數(shù)、以及初始治療方案與HAART保持時間長短有顯著關(guān)聯(lián)。結(jié)論云南省德宏州HAART保持率相對較好,但隨著治療時間延長呈下降趨勢。需要針對不同特征的患者采取有針對性的措施來提高依從性。
[Abstract]:Objective to understand the maintenance rate and its influencing factors of high effective antiretroviral therapy (HART) among HIV infected persons in Dehong, Yunnan province from 2004 to 2013. Methods A dynamic cohort study was conducted with the time of beginning antiviral therapy as the time of entering the queue. The retention rate of HAART was calculated at different follow-up times. The possible factors were analyzed by Cox proportional risk regression model. Results from 2004 to 2013, a total of 7580 people were admitted to the group, and the Chinese nationality was the most, accounting for 84.1%, Yingjiang County was the most in the five counties (26.3%), the male was the main group (62.2%), the average age was 36.9 鹵10.0 years (2635 years). Marital status was mainly married, accounting for 70.9% of HIV infection route was mainly sexually transmitted, accounting for 68.3%, baseline CD4 T lymphocyte count 鈮，

本文編號：1835358