本文選題：丙型肝炎 + 病毒�。� 參考：《北京醫(yī)學(xué)》2013年03期

【摘要】：目的探討慢性丙型肝炎病毒(HCV)感染者血清中自身抗體檢測的臨床意義。方法對(duì)119例慢性HCV感染者及40例健康體檢者的血清標(biāo)本進(jìn)行抗核抗體(ANA)、抗可提取性核抗原(ENA)抗體、類風(fēng)濕因子(RF)檢測,比較其陽性率,并分析自身抗體與年齡、性別、民族、肝功能指標(biāo)及病毒復(fù)制的關(guān)系。結(jié)果 119例慢性HCV感染者中有64例檢測出至少1項(xiàng)自身抗體,陽性率為53.8%,40例健康對(duì)照者中有3例檢測出至少1項(xiàng)自身抗體,陽性率為7.5%,兩組檢出率的差異有統(tǒng)計(jì)學(xué)意義(P0.05)。HCVRNA陽性組中自身抗體檢出率為64.6%,HCVRNA陰性組檢出率為40.7%,兩組檢出率的差異有統(tǒng)計(jì)學(xué)意義(P0.05)。自身抗體陽性組與陰性組的性別、民族比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05),年齡≥40歲患者的構(gòu)成比差異有統(tǒng)計(jì)學(xué)意義(P0.05)。自身抗體陽性組丙氨酸氨基轉(zhuǎn)移酶、天冬氨酸氨基轉(zhuǎn)移酶、總膽紅素均高于陰性組(P0.05)。結(jié)論 HCV感染能誘導(dǎo)自身免疫反應(yīng),產(chǎn)生多種自身抗體,自身抗體的檢出率與年齡和病毒復(fù)制有關(guān),自身免疫可能是HCV感染后組織損傷的重要因素。HCV感染者有必要做自身抗體檢測。
[Abstract]:Objective to investigate the clinical significance of serum autoantibodies in patients with chronic hepatitis C virus (HCV) infection. Methods Serum samples of 119 patients with chronic HCV infection and 40 healthy controls were tested for antinuclear antibody (Ana), anti-extractable nuclear antigen (na) antibody and rheumatoid factor (RF). The relationship between liver function and virus replication. Results 64 out of 119 cases of chronic HCV infection detected at least one autoantibody, the positive rate was 53.8% and 3 out of 40 healthy controls detected at least 1 autoantibody. The positive rate was 7.5. The difference between the two groups was statistically significant. The detection rate of autoantibody in the positive group was 64.6and the positive rate of HCV RNA was 40.7. The difference between the two groups was statistically significant (P 0.05). There was no significant difference in sex and nationality between autoantibody positive group and negative group (P 0.05), but there was significant difference in composition ratio of patients aged 鈮，

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