本文選題：炎癥因子 + 血流感染��； 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年21期

【摘要】：目的探討血清炎癥因子表達(dá)水平在血流感染性疾病中與病原菌、病情程度及預(yù)后的相關(guān)性。方法采用回顧性分析2015年1月-2016年5月該院收治的97例血流感染性疾病患者作為研究對(duì)象,根據(jù)患者病情、病原菌種類及治療效果等來分析血清炎性因子降鈣素原(PCT)、C-反應(yīng)蛋白(CRP)、白細(xì)胞介素6(IL-6)、白細(xì)胞數(shù)(WBC)及腫瘤壞死因子α(TNF-α)的表達(dá)水平在血流感染性疾病中的變化。結(jié)果血培養(yǎng)陽性的血流感染性疾病患者的血清炎癥因子水平普遍高于血培養(yǎng)陰性患者的血清炎癥因子水平,兩者比較差異有統(tǒng)計(jì)學(xué)意義[PCT(t=170.410,P=0.000);IL-6(t=187.223,P=0.000);WBC(t=19.244,P=0.000);CRP(t=47.941,P=0.000);TN F-α(t=20.484,P=0.000)];血清炎癥因子PCT、IL-6、WBC、CR P及TN F-α表達(dá)水平在革蘭陰性菌組中最高,真菌組最低,三者間比較差異有統(tǒng)計(jì)學(xué)意義[PCT(F=5.367,P=0.019);IL-6(F=10.321,P=0.001);WBC(F=9.587,P=0.000);CR P(F=15.894,P=0.000);TN F-α(F=13.254,P=0.000)];各組血清炎癥因子表達(dá)水平有差異,進(jìn)一步兩兩比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療無效的血流感染性疾病患者的血清炎癥因子表達(dá)水平均升高,治療前后兩者比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療好轉(zhuǎn)的血流感染性疾病患者血清炎癥因子表達(dá)水平均下降,治療前后兩者比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療好轉(zhuǎn)組與治療無效組血流感染性疾病患者的血清炎性因子表達(dá)水平在治療前后差值比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論血清炎性因子表達(dá)水平與血流感染性疾病的嚴(yán)重程度、病原菌種類等有一定相關(guān)性,對(duì)治療效果的早期判斷有一定參考價(jià)值。
[Abstract]:Objective to investigate the relationship between the expression of serum inflammatory factors and pathogenic bacteria, severity and prognosis in blood stream infectious diseases.Methods from January 2015 to May 2016, 97 patients with blood flow infection were analyzed retrospectively.The types of pathogenic bacteria and the therapeutic effects were used to analyze the changes of the expression levels of serum inflammatory cytokines, such as the levels of serum inflammatory cytokines, such as CRP, IL-6, WBC- 偽 and TNF- 偽, in blood stream infectious diseases.Results the levels of serum inflammatory cytokines in patients with blood stream infectious diseases were higher than those in patients with negative blood culture.There were significant differences between the two groups [the expression levels of IL-6T 187.223P0.000 were the highest in the Gram-negative group and the lowest in the fungus group, and the expression levels of TN F- 偽 T20.484P0.000 were the lowest in the Gram-negative bacteria group, and the expression levels of TNF- 偽 and TNF- 偽 were the highest in the Gram-negative group, and the highest in the fungus group, and the highest in the Gram-negative group, and the highest in the fungus group, and the highest in the Gram-negative bacteria group, and the highest in the fungus group, and the highest in the Gram-negative bacteria group, and the highest in the fungus group, and the highest in the Gram-negative bacteria group, and the highest in the fungus group, and the highest in the Gram-negative bacteria group, and the highest in the fungus group.There were significant differences among the three groups [the expression level of IL-6FN 10.321 P0. 001WBCCU F9. 587P0. 000 was significantly different among the three groups], and the expression level of serum inflammatory factors was different among the three groups (P 0. 05 0. 000), and the level of serum inflammatory factors in each group was different, and the difference was statistically significant (P 0. 05 0. 0. 0. 05, P < 0. 05), and there was no significant difference between the two groups in the expression of serum inflammatory factors (P 0. 050), and there was no significant difference between the two groups in the expression of TNF- 偽 F- 偽 F- 偽 F13. 254P0. 000 (P < 0. 05).The levels of serum inflammatory cytokines in patients with blood flow infectious diseases without effective treatment were significantly higher than those before and after treatment (P 0.05), and the expression levels of serum inflammatory factors in patients with improved blood flow infectious diseases were all lower than those before and after treatment, and there was no significant difference between the two groups before and after treatment.There was significant difference between the two groups before and after treatment (P 0.05).The expression of serum inflammatory factors in patients with blood flow infectious diseases was significantly different before and after treatment between the treatment group and the ineffective group (P 0.05).Conclusion the expression level of serum inflammatory factors is correlated with the severity of blood stream infectious diseases and the types of pathogenic bacteria, which has some reference value for the early judgement of therapeutic effect.
【作者單位】： 川北醫(yī)學(xué)院附屬醫(yī)院感染科;首都醫(yī)科大學(xué);
【分類號(hào)】：R51

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