本文選題：結(jié)核性腦膜炎　切入點(diǎn)：早期分泌性抗原靶-6　出處：《廣西醫(yī)科大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：系統(tǒng)評(píng)價(jià)腦脊液(CSF)單核細(xì)胞內(nèi)早期分泌性抗原靶-6(ESAT-6)診斷結(jié)核性腦膜炎(TBM)的價(jià)值； 方法：計(jì)算機(jī)檢索PubMed、EMbase、Cochrane圖書館、中國(guó)醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、中國(guó)知網(wǎng)、維普數(shù)據(jù)庫及萬方數(shù)據(jù)庫的關(guān)于腦脊液?jiǎn)魏思?xì)胞內(nèi)ESAT-6診斷結(jié)核性腦膜炎的中文及英文文獻(xiàn),檢索時(shí)間截至2012年12月。由兩名評(píng)價(jià)者按照納入和排除標(biāo)準(zhǔn)選擇文獻(xiàn)、依據(jù)QUADAS質(zhì)量評(píng)價(jià)標(biāo)準(zhǔn)評(píng)價(jià)納入研究的質(zhì)量后,提取資料,采用Meta-disc1.4軟件對(duì)納入文獻(xiàn)進(jìn)行異質(zhì)性檢驗(yàn)及數(shù)據(jù)分析,通過合并敏感度、特異度、陽性似然比、陰性似然比、診斷比值比及受試者工作特征曲線(SROC曲線)等統(tǒng)計(jì)指標(biāo)綜合評(píng)價(jià)ESAT-6對(duì)結(jié)核性腦膜炎的診斷價(jià)值。 結(jié)果：共納入7篇文獻(xiàn),樣本含量為482例,其中診斷為結(jié)核性腦膜炎的患者為243例。異質(zhì)性檢驗(yàn)顯示各研究結(jié)果間無明顯異質(zhì)性,通過固定效應(yīng)模型的匯總計(jì)算得出：合并敏感度0.84(95%,CIO.79-0.89),合并特異度0.93(95%,0.89-0.96),陽性似然比(PLR)11.75(95%,7.43-18.58),陰性似然比(NLR)0.16(95%,0.12-0.22),診斷比值比(DOR)71.65(95%,38.69-132.70), SROC曲線下面積(AUC)0.9528。 結(jié)論：ESAT-6可作為診斷結(jié)核性腦膜炎較重要的參考指標(biāo)之一。
[Abstract]:Objective: to evaluate the value of early secretory antigen target 6 (ESAT-6) in the diagnosis of tuberculous meningitis (TBM) in cerebrospinal fluid (CSF) monocytes. Methods: the Chinese and English literatures on the diagnosis of tuberculous meningitis with intracellular ESAT-6 in cerebrospinal fluid (CSF) were searched on PubMedus Embase Cochrane Library, Chinese Medical Literature Database, China knowledge Network, Weip Database and Wanfang Database. The retrieval time was up to December 2012. Two evaluators selected the literature according to the inclusion and exclusion criteria, and then extracted the data according to the QUADAS quality evaluation criteria. The heterogeneity test and data analysis were carried out by using Meta-disc1.4 software. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and negative likelihood ratio were combined, and the negative likelihood ratio was analyzed by combining sensitivity, specificity, positive likelihood ratio and negative likelihood ratio. The diagnostic value of ESAT-6 in the diagnosis of tuberculous meningitis was evaluated synthetically by the diagnostic ratio ratio and the operating characteristic curve of the subjects. Results: a total of 7 articles were included, and the sample size was 482, including 243 patients diagnosed as tuberculous meningitis. The heterogeneity test showed that there was no significant heterogeneity among the results of the study. Through the summary calculation of fixed effect model, it was found that the combined sensitivity was 0.84 ~ 95g / CIO.79-0.89, the combined specificity was 0.939 ~ 0.96, the positive likelihood was 7.43-18.58, the negative likelihood ratio was 0.16950.12-0.22, the diagnostic ratio was 71.659595 / 38.69-132.70, and the area under SROC curve was 0.9528. Conclusion: ESAT-6 can be used as an important index in the diagnosis of tuberculous meningitis.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R529.3

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本文編號(hào)：1645700