本文選題：乙型肝炎病毒　切入點：乙型肝炎病毒定量　出處：《新疆醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:研究乙型肝炎病毒與慢性乙型肝炎患者臨床常用血糖代謝指標的相關(guān)性。方法：選取2011年9月至2013年10月期間在新疆醫(yī)科大學(xué)第五附屬醫(yī)院內(nèi)分泌科就診的慢性乙型肝炎病史小于5年的新發(fā)糖尿病患者128人,對其乙肝病毒DNA定量數(shù)量與臨床常用血糖代謝指標進行嶺回歸分析。結(jié)果：排除混雜因素的影響后行嶺回歸提示乙肝病毒DNA數(shù)量與血糖水平(r=0.297,P0.001；r=0.156,P0.001; r=0.656,P0.001；r0.432,P0.001；r=0.649,P0.001).胰島素水平(r=0.305,P0.001；r=0.476,P0.001；r=0.395,P0.001；r=0.386,P0.001；r=0.561,P0.001).C肽水平(r=0.251,P0.001；r=0.229,P0.001；r=0.254,P0.001；r=0.075,P0.001； r=0.252,P=0.010)、胰島素抵抗指數(shù)(r=0.187,P0.001)、胰島p細胞功能指數(shù)(r=0.517,P0.001)呈正性相關(guān),與胰島素敏感指數(shù)(r=-0.159,P0.001)、胰島素作用指數(shù)(r=-0.140,P0.001)呈負性相關(guān)。結(jié)論：隨著乙肝病數(shù)量的升高,血糖水平呈上升趨勢,刺激胰島β細胞大量分泌胰島素,胰島素抵抗加重,降低胰島素敏感性,影響胰島素的生理作用,從而引起或進一步加重血糖代謝紊亂程度。
[Abstract]:Objective: to study the correlation between hepatitis B virus (HBV) and blood glucose metabolism in patients with chronic hepatitis B. methods: from September 2011 to October 2013, we visited the Department of Endocrinology, 5th affiliated Hospital of Xinjiang Medical University. 128 new diabetic patients with chronic hepatitis B with a history of less than 5 years, The quantitative quantity of hepatitis B virus (DNA) and blood glucose metabolism index were analyzed by ridge regression analysis. Results: the results showed that the quantity of hepatitis B virus DNA and blood glucose level were 0.297g P 0.001 P 0.001 P 0.001; 0.656U P 0.001r0.432P 0.001r0.649p 0.001P 0.001.The insulin level was 0.305p 0.476p 0.395p 0.395P 0.001p 0.001 P 0.001P 0.001P 0.001P 0.001p 0.561p 0.561p 0.001p ~ 0.561p ~ 0.561p ~ (0.001) P ~ (0.001) P ~ (0.001) P ~ (?) ~ P ~ (?) ~ (?) ~ (?) ~ (?) ~ (?) _ _ _. There was a positive correlation between the levels of 0.251 (0.251) and 0.229 (P 0.001), 0.254 (P 0.001), 0.075 (P 0.001), 0.010 (0.252), 0.187 (P 0.001) and r0.517 (P 0.001) of the islet cell function index (P0. 017), the insulin resistance index (0. 187) and the islet P cell function index (r0. 517) were positively correlated with that of the pancreatic islet P cell function index (P0. 001), the insulin resistance index was 0. 187%, and the insulin resistance index was 0. There was a negative correlation between the insulin sensitivity index and insulin sensitivity index (r-0.159U, P 0.001). Conclusion: with the increase of hepatitis B disease, the level of blood sugar is increasing, which stimulates the secretion of insulin by 尾 -cells and increases insulin resistance. Reduce insulin sensitivity, affect the physiological effect of insulin, and cause or further aggravate the disorder of blood glucose metabolism.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R587.1;R512.62

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