本文選題：長效干擾素　切入點：慢性乙型肝炎　出處：《南方醫(yī)科大學學報》2017年09期 　論文類型：期刊論文

【摘要】：目的分析長效干擾素(Peg IFN)治療慢性乙型肝炎(CHB)引發(fā)的精神心理異常發(fā)生率,評估艾司西酞普蘭和阿普唑侖干預對PegIFN所致抑郁和焦慮癥狀的療效。方法 165例接受PegIFN治療的CHB患者,治療12周后,使用抑郁篩查量表(PHQ-9)和焦慮篩查量表(GAD-7)對其進行精神心理學評估;對篩選出的中重度抑郁和中重度焦慮的患者,采用艾司西酞普蘭或阿普唑侖干預,分別于干預用藥后第2、4、8周隨訪抑郁和焦慮癥狀的緩解程度,評估艾司西酞普蘭和阿普唑侖分別對抑郁和焦慮的治療效果。結(jié)果經(jīng)量表檢出并由精神科醫(yī)師確認,37例為中重度抑郁,發(fā)生率為22.4%;31例為中重度焦慮,發(fā)生率為18.8%;其中,合并中重度抑郁和中重度焦慮的有17例,發(fā)生率為10.3%。艾司西酞普蘭對抑郁和焦慮均有較好療效(P=0.000),阿普唑侖對焦慮效果顯著(P=0.001),但對抑郁效果不明顯(P=0.904);在焦慮的改善方面,阿普唑侖比艾司西酞普蘭療效要好(t=-3.198,P=0.010)。結(jié)論 Peg IFN引發(fā)的抑郁和焦慮癥狀在我國CHB患者中發(fā)生率較高,應注意精神心理異常的評估;及時使用艾司西酞普蘭或者阿普唑侖對Peg IFN引發(fā)的抑郁和焦慮癥狀有較好的療效;同時可明顯提高患者接受PegIFN治療的依從性。
[Abstract]:Objective to analyze the incidence of psychosomatic abnormalities induced by long-term interferon peg IFN in the treatment of chronic hepatitis B (CHB). To evaluate the efficacy of escitalopram and alprazolam in the treatment of depression and anxiety caused by PegIFN. Methods 165 patients with CHB treated with PegIFN were treated for 12 weeks. The depression screening scale (PHQ-9) and anxiety screening scale (GAD-7) were used to evaluate the mental psychology, and the patients with moderate and severe depression and anxiety were treated with Escitalopram or alprazolam. The degree of remission of depression and anxiety were followed up at the 2nd week and 4th week after the intervention. Results 37 patients with moderate and severe depression and 31 patients with moderate and severe anxiety were diagnosed by the scale and confirmed by psychiatrists, and the incidence rate was 18.8. There were 17 patients with moderate and severe depression and moderate and severe anxiety, the incidence rate was 10.3.The alprazolam had a good effect on both depression and anxiety. Alprazolam had a significant effect on anxiety, but it had no significant effect on depression, and on the improvement of anxiety, alprazolam had a significant effect on anxiety, but the effect of alprazolam on depression was not obvious. Alprazolam was more effective than escitalopram. Conclusion the incidence of depression and anxiety caused by Peg IFN is higher in CHB patients in China. Timely use of Escitalopram or alprazolam has a good effect on depression and anxiety caused by PegIFN, and can significantly improve the compliance of patients with PegIFN.
【作者單位】： 南方醫(yī)科大學南方醫(yī)院感染內(nèi)科;南方醫(yī)科大學南方醫(yī)院肝膽外科;南方醫(yī)科大學中西醫(yī)結(jié)合醫(yī)院外二科;南方醫(yī)科大學南方醫(yī)院心理科;
【基金】：國家自然科學基金(81470856) 中國肝炎防治基金會課題(XJS20120601)~~
【分類號】：R512.62
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本文編號：1638339