本文選題：乙型病毒性肝炎　切入點(diǎn)：乙型肝炎病毒　出處：《泰山醫(yī)學(xué)院》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的 乙型病毒性肝炎（簡(jiǎn)稱乙肝）系由乙型肝炎病毒（hepatitis virus B,HBV）所引起的一種肝臟疾病，主要經(jīng)輸血、注射和母嬰傳播。HBV屬于獨(dú)特的嗜肝DNA病毒，是已知真核細(xì)胞中最小的DNA病毒，結(jié)構(gòu)緊湊，，功能齊全。乙肝常導(dǎo)致慢性感染，有15%～40%未經(jīng)抗病毒治療的患者將進(jìn)展為終末期肝病，如肝硬化、肝衰竭及肝癌等。乙型肝炎病毒感染亦是一種全身性傳染性疾病，膽囊與肝臟緊鄰，肝臟分泌的膽汁在膽囊內(nèi)貯存，膽囊有可能成為HBV侵犯的靶器官。膽系疾病以膽囊炎、膽石癥多見，本課題以膽囊炎、膽石癥做為主要研究對(duì)象；探討膽系疾病與乙肝病毒感染的關(guān)系。方法 隨機(jī)抽取符合《外科學(xué)》(第7版)診斷標(biāo)準(zhǔn)的膽囊炎膽石癥患者60例為膽系疾病組，均化驗(yàn)肝功能等指標(biāo)，檢測(cè)該組HBsAg的陽性率；另隨機(jī)抽取我院2012年至2013年收住的非肝膽疾病患者60例作為對(duì)照組，收錄標(biāo)準(zhǔn)：均行肝膽超聲檢查并化驗(yàn)肝功能、血凝等指標(biāo)正常，檢測(cè)該組HBsAg的陽性率，與膽系疾病組做比較。 結(jié)果 （1）膽系疾病組乙肝病毒感染率為70.0%，對(duì)照組乙肝病毒感染率達(dá)13.3%。 （2）膽系疾病患者中乙肝的發(fā)生與ALT、BIL呈正相關(guān)，與A/G呈負(fù)相關(guān)。 （3）膽系疾病合并乙肝患者男性多于女性。 結(jié)論 膽囊炎、膽石病的發(fā)生與乙肝病毒感染有明顯的相關(guān)關(guān)系。
[Abstract]:Purpose. Hepatitis B virus (HBV) is a kind of liver disease caused by hepatitis B virus hepatitis B (HBV). It is mainly transfusions, injections and mother-to-child transmission. HBV belongs to the unique Hepatophilic DNA virus and is the smallest known DNA virus in eukaryotic cells. Hepatitis B often causes chronic infection. 15% of patients without antiviral treatment will progress to end-stage liver disease, such as liver cirrhosis, liver failure, liver cancer, etc. Hepatitis B virus infection is also a systemic infectious disease. The bile secreted by the liver is stored in the gallbladder and the gallbladder may become the target organ of HBV invasion. Cholecystitis and cholelithiasis are the common diseases of the gallbladder. Cholecystitis and cholelithiasis are the main research objects in this paper. To explore the relationship between biliary diseases and hepatitis B virus infection. Sixty patients with cholecystitis and cholelithiasis who met the diagnostic criteria of surgery (7th edition) were randomly selected as biliary disease group. The liver function was tested and the positive rate of HBsAg in this group was detected. From 2012 to 2013, 60 patients with non-hepatobiliary diseases were randomly selected as the control group. The criteria included: liver and bile ultrasound examination, liver function test, blood coagulation and other indexes were normal, the positive rate of HBsAg in this group was detected. A comparison was made with the group of biliary diseases. Results. 1) the infection rate of hepatitis B virus was 70.0 in the group of biliary diseases and 13.3in the control group. 2) the incidence of hepatitis B was positively correlated with alt BIL and negatively correlated with A / G in patients with biliary diseases. 3) there were more men than women in patients with biliary diseases complicated with hepatitis B. Conclusion. Cholecystitis, cholelithiasis and hepatitis B virus infection have obvious correlation.
【學(xué)位授予單位】：泰山醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R512.62;R575.6

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