本文選題：肝硬化　切入點(diǎn)：膽汁性　出處：《現(xiàn)代醫(yī)藥衛(wèi)生》2016年22期 　論文類型：期刊論文

【摘要】：目的比較單純原發(fā)性膽汁性膽管炎(PBC)患者、單純乙型病毒性肝炎(乙肝)患者及PBC-乙肝重疊綜合征患者的臨床特點(diǎn),分析并總結(jié)PBC-乙肝重疊綜合征患者臨床特征。方法回顧性分析從江蘇省PBC協(xié)作組臨床資料庫(作者系協(xié)作組成員)中采用簡單隨機(jī)抽樣方法隨機(jī)篩選2007~2015年診治并已確診的104例單純PBC患者(A組)、93例單純乙肝患者(B組)、29例PBC-乙肝重疊綜合征患者(C組)的臨床資料,對患者年齡、性別及血清檢測結(jié)果進(jìn)行統(tǒng)計(jì)分析。結(jié)果 A、C組患者中女性明顯多于男性,且A組患者中女性明顯多于C組,差異均有統(tǒng)計(jì)學(xué)意義(P0.01);C組患者年齡明顯高于B組,差異有統(tǒng)計(jì)學(xué)意義(P0.01),但與A組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);C組患者丙氨酸氨基轉(zhuǎn)移酶(ALT)、天門冬氨酸氨基轉(zhuǎn)移酶(AST)、總蛋白、清蛋白、免疫球蛋白(A、G、M)水平與A、B組比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05),但γ-谷氨酰轉(zhuǎn)移酶(GGT)、堿性磷酸酶(ALP)水平明顯低于A組,高于B組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);C組患者總膽紅素、直接膽紅素水平與A組比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05),但高于B組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論乙肝患者經(jīng)藥物治療后若ALT、AST水平降低而GGT、ALP、膽紅素水平無明顯改善時(shí)需進(jìn)行抗線粒體抗體亞型檢測,以確診是否伴PBC。
[Abstract]:Objective to compare the clinical characteristics of patients with primary biliary cholangitis (PBC), patients with simple viral hepatitis B (HBV) and patients with PBC- hepatitis B overlap syndrome. The clinical characteristics of patients with PBC- hepatitis B overlap syndrome were analyzed and summarized. Methods A retrospective analysis was made on the clinical data base of Jiangsu Province PBC Co-operative Group (the author was a member of the Co-operative Group), who were randomly selected for diagnosis and treatment from 2007 to 2015 by using a simple random sampling method. Clinical data of 93 patients with simple hepatitis B and 29 patients with PBC- hepatitis B overlap syndrome (group C). Results the age, sex and serum levels of patients in group A were significantly higher than those in group C, and the number of women in group A was significantly higher than that in group C. the difference was statistically significant (P 0.01) and the age of group C was significantly higher than that of group B. The difference was statistically significant (P 0.01), but there was no significant difference between group A and group A in the levels of alanine aminotransferase (alt), aspartate aminotransferase (ASTT), total protein, albumin and immunoglobulin A (GN) in group A (P 0.05). There was no significant difference in the levels of total bilirubin and direct bilirubin between group A and group A, but the levels of GGTN and ALP in group A were significantly lower than those in group A and higher than those in group B. there were significant differences in total bilirubin and direct bilirubin levels between group A and group A, and the levels of total bilirubin and direct bilirubin in group C were significantly higher than those in group A. The difference was not statistically significant, but it was higher than that in group B, and the difference was statistically significant. Conclusion the anti-mitochondrial antibody subtype should be detected in patients with hepatitis B when the level of alt AST decreases and the level of GGTN ALP and bilirubin does not improve obviously after drug therapy. To confirm whether PBC was associated with PBC.
【作者單位】： 江蘇大學(xué)附屬昆山醫(yī)院消化科;無錫市第五人民醫(yī)院檢驗(yàn)科;鎮(zhèn)江市第三人民醫(yī)院檢驗(yàn)科;
【基金】：江蘇省自然科學(xué)基金面上項(xiàng)目(BK20130607)
【分類號】：R512.62;R575.7
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本文編號：1616037