本文選題：慢性乙型肝炎　切入點：DNA載量　出處：《石河子大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的通過研究BeAg陽性和陰性慢性乙型肝炎(CHB)患者血清HBV DNA載量與ALT、APRI及FIB-4值的相關(guān)性,了解在不同的HBe Ag表達狀態(tài)下血清HBV DNA水平對監(jiān)測病情進展的不同應(yīng)用價值。方法收集111例CHB患者的基本資料及血清HBV DNA載量、丙氨酸氨基轉(zhuǎn)移酶(ALT)、天冬氨酸氨基轉(zhuǎn)移酶(AST)、血小板(PLT)水平等血清學(xué)資料,運用公式計算出APRI及FIB-4指數(shù)值,并將丙氨酸氨基轉(zhuǎn)移酶(ALT)作為炎癥指標,將APRI及FIB-4指數(shù)作為肝臟纖維化指標進行相關(guān)性研究。采用SPSS21.0軟件進行相關(guān)性統(tǒng)計分析及Graphpad Prism 5軟件進行統(tǒng)計圖繪制。結(jié)果HBeAg陰性CHB患者血清HBV DNA載量較HBeAg陽性CHB患者的低(Z=-3.684,P0.01);兩組ALT及APRI的差異均無統(tǒng)計學(xué)意義(Z1=-0.968,P0.05;Z2=-0.808,P0.05);HBeAg陰性CHB患者FIB-4值高于HBeAg陽性CHB患者(Z=-2.266,P0.05)。HBeAg陰性CHB患者的年齡比HBeAg陽性CHB患者的大,差異有統(tǒng)計學(xué)意義(t=3.859,P0.01)。HBe Ag陰性CHB患者血清HBV DNA載量與ALT呈正相關(guān)(r=0.347,P0.01),與APRI呈顯著正相關(guān)(r=0.648,P0.01),與FIB-4值呈顯著正相關(guān)(r=0.596,P0.01);HBeAg陽性CHB患者血清HBV DNA載量與ALT、APRI及FIB-4值均無相關(guān)性(P值均大于0.05)。結(jié)論血清HBV DNA水平可較好反映出HBe Ag陰性CHB患者肝組織炎癥及纖維化程度;但不能體現(xiàn)出HBeAg陽性CHB患者的肝組織炎癥及纖維化程度。
[Abstract]:Objective to study the correlation between serum HBV DNA load and alt APRI and FIB-4 in patients with BeAg positive and negative chronic hepatitis B (CHB). To understand the value of serum HBV DNA level in monitoring the disease progression in different HBe Ag expression states. Methods the basic data and serum HBV DNA load were collected in 111 patients with CHB. Serum levels of alanine aminotransferase (alt), aspartate aminotransferase (AST) and platelets (PLT) were calculated by using the formula to calculate the values of APRI and FIB-4, and alanine aminotransferase (alt) was used as an inflammatory index. The correlation between APRI and FIB-4 index as hepatic fibrosis index was studied. SPSS21.0 software was used to analyze the correlation and Graphpad Prism 5 software was used to plot the correlation. Results the HBV DNA load in HBeAg negative CHB patients was higher than that in HBeAg positive CHB patients. There was no significant difference in ALT and APRI between the two groups (P < 0.05). The FIB-4 value of the patients with CHB was higher than that of the patients with HBeAg positive CHB. The age of patients with HBeAg-negative CHB was higher than that of patients with HBeAg CHB. There was a significant difference between serum HBV DNA load and ALT in CHB patients with negative HBe Ag and 3.859p 0.01n. HBe Ag negative patients. There was a significant positive correlation between HBV DNA load and ALT, a significant positive correlation with APRI, and a significant positive correlation with FIB-4 value. There was no significant correlation between the HBV DNA load and the values of ALT and FIB-4 in CHB patients with HBeAg positive CHB. There was no significant correlation between HBV DNA load and the values of ALT and FIB-4 in patients with HBeAg positive CHB. Conclusion the level of serum HBV DNA can well reflect the degree of liver inflammation and fibrosis in patients with HBe Ag negative CHB. But it can not reflect the degree of inflammation and fibrosis in liver tissue of HBeAg positive CHB patients.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R512.62

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相關(guān)期刊論文 前10條

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本文編號：1585992