本文選題：單純皰疹病毒　切入點：心房顫動　出處：《中華醫(yī)院感染學(xué)雜志》2017年12期 　論文類型：期刊論文

【摘要】：目的探討單純皰疹病毒感染與心房顫動的關(guān)系,為臨床診治提供依據(jù)。方法選取2014年1月-2016年12月醫(yī)院收治的房顫患者96例,其中陣發(fā)性房顫68例,持續(xù)性房顫28例。另選同期醫(yī)院健康體檢者100例為對照組;所有研究對象于清晨采集空腹血,檢測HSV-1抗體和HSV-2抗體,C-反應(yīng)蛋白(CRP)、胱氨酸蛋白酶抑制劑C(Cyc)和血脂指標(biāo)[總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)和低密度脂蛋白膽固醇(LDL-C)]。結(jié)果陣發(fā)性房顫組和持續(xù)性房顫組血清HSV-1抗體和HSV-2抗體水平均顯著高于對照組(P0.01),陣發(fā)性房顫組和持續(xù)性房顫組血清HSV-1抗體和HSV-2抗體水平比較差異無統(tǒng)計學(xué)意義;陣發(fā)性房顫組和持續(xù)性房顫組血清HSV-1抗體陽性率、HSV-2抗體陽性率、CRP、Cyc、TC、TG和LDL-C水平均顯著高于對照組,HDL-C水平顯著低于對照組(P0.05),陣發(fā)性房顫組和持續(xù)性房顫組各指標(biāo)比較差異均無統(tǒng)計學(xué)意義;血清HSV-1抗體和HSV-2抗體與CRP呈明顯正相關(guān)性(r=0.669,P=0.012;r=0.531,P=0.018);血清HSV-1抗體和HSV-2抗體與Cyc呈明顯正相關(guān)性(r=0.605,P=0.015;r=0.453,P=0.032)。結(jié)論 HSV感染可能通過炎癥反應(yīng)和影響血脂正常代謝等過程,直接或間接地參與房顫的形成過程。
[Abstract]:Objective to investigate the relationship between herpes simplex virus infection and atrial fibrillation, and to provide evidence for clinical diagnosis and treatment. Methods 96 patients with atrial fibrillation were selected from January 2014 to December 2016, including 68 patients with paroxysmal atrial fibrillation. 28 cases of persistent atrial fibrillation. 100 cases of health check-up in the same period were selected as control group. All the subjects collected fasting blood in the early morning. The levels of HSV-1 antibody and HSV-2 antibody C reactive protein (HSV-2), cystine protease inhibitor (cystine), and serum lipids were determined. Results the results of paroxysmal atrial fibrillation group were as follows: total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). The levels of serum HSV-1 antibody and HSV-2 antibody in patients with paroxysmal atrial fibrillation and persistent atrial fibrillation were significantly higher than those in control group (P 0.01). There was no significant difference in the levels of serum HSV-1 antibody and HSV-2 antibody between paroxysmal atrial fibrillation group and persistent atrial fibrillation group. Serum HSV-1 Antibody positive rate and HSV-2 Antibody positive rate in paroxysmal Atrial Fibrillation Group and persistent Atrial Fibrillation Group; the levels of TG and LDL-C in the serum HSV-2 antibody of patients with paroxysmal atrial fibrillation and persistent atrial fibrillation were significantly higher than those of the control group (P 0.05). The indexes of paroxysmal atrial fibrillation group and persistent atrial fibrillation group were lower than those of the control group. There was no significant difference between the two groups. There was a positive correlation between serum HSV-1 antibody and HSV-2 antibody and CRP. There was a positive correlation between serum HSV-1 antibody and HSV-2 antibody and Cyc. Conclusion HSV infection may be through inflammatory reaction and affect the normal metabolism of blood lipid. Participate directly or indirectly in the formation of atrial fibrillation.
【作者單位】： 錦州醫(yī)科大學(xué)附屬三院心血管內(nèi)三科;錦州醫(yī)科大學(xué)附屬三院檢驗科;
【基金】：遼寧省教育科學(xué)“十二五”規(guī)劃基金資助項目(JG15DB233)
【分類號】：R541.75;R752.11
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本文編號：1570527