本文關(guān)鍵詞： 慢乙肝 脂肪變性 肝臟病理　出處：《新疆醫(yī)科大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：了解單純慢乙肝與慢乙肝合并脂肪變者的肝臟病變特點及臨床差異,尋找與肝纖維化改變相關(guān)的危險因素。方法：分析275例HBsAg陽性患者的肝組織病理情況，將病例分為單純乙肝組和乙肝合并脂肪變組,比較兩組在年齡、腰圍、尿酸、血脂方面的差異,分析各危險因素對肝臟纖維化的影響。并比較不同水平的脂肪變患者在相關(guān)指標及炎癥纖維化水平上的差異，統(tǒng)計學(xué)處理采用SPSS統(tǒng)計軟件，P＜0.05為差異有統(tǒng)計學(xué)意義。結(jié)果：275例乙肝患者中有脂肪變性者104例。慢乙肝合并脂肪肝組相比單純慢乙肝組在腰圍，尿酸，BMI，血脂水平上存在差異。年齡，炎癥水平分級，飲酒以及HBeAg陰性狀態(tài)是慢乙肝患者纖維化進展加重的獨立危險因素；脂肪沉積對肝臟纖維化的影響為負相關(guān)。不同水平的脂肪變病人在性別，，腰圍，尿酸，血脂方面有著明顯差異（P 0.05），高水平的脂肪變有著更高水平的炎癥。結(jié)論:血脂紊亂，肥胖等代謝綜合征是肝細胞脂肪變性的主要原因，而與酒精無關(guān)，脂肪變會加重慢乙肝患者肝臟炎癥程度。其中年齡，炎癥水平, e抗原陰性狀態(tài)，飲酒是CHB（Hepatitis B virus infection）患者肝組織纖維化進展相關(guān)的獨立危險因素,但隨著纖維化程度的加重,肝細胞脂肪變反而減輕.
[Abstract]:Objective: to investigate the characteristics and clinical differences of hepatic pathological changes in patients with chronic hepatitis B (CHB) and chronic hepatitis B (CHB) complicated with fatty change, and to find out the risk factors associated with hepatic fibrosis. Methods: the pathological changes of liver tissues in 275 patients with HBsAg positive were analyzed. The patients were divided into simple hepatitis B group and hepatitis B combined with fat group. The difference of age, waist circumference, uric acid, blood lipids between the two groups was compared. The effects of various risk factors on liver fibrosis were analyzed. Results there were 104 cases of fatty degeneration among 275 cases of hepatitis B. the waist circumference of chronic hepatitis B combined with fatty liver group was higher than that of chronic hepatitis B group (P < 0. 05). Age, grade of inflammation, alcohol consumption and HBeAg negative state were independent risk factors for exacerbation of fibrosis in patients with chronic hepatitis B. There were significant differences in sex, waist circumference, uric acid and blood lipids in patients with different levels of fat deposition, and there was a higher level of inflammation in high levels of fatty degeneration. Conclusion: dyslipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, and hyperlipidemia are associated with high levels of inflammation. Obesity and other metabolic syndrome are the main causes of hepatocyte steatosis, but are not related to alcohol. Fatty degeneration can aggravate the degree of liver inflammation in patients with chronic hepatitis B. among them, age, inflammation level, e antigen negative state, Alcohol consumption is an independent risk factor related to the progression of hepatic fibrosis in patients with CHB(Hepatitis B virus Infection.However, with the exacerbation of fibrosis, the fatty change of hepatocytes decreases.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R512.62

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