本文關(guān)鍵詞： 馬爾尼菲青霉菌病 伏立康唑 兩性霉素B 艾滋病　出處：《中國艾滋病性病》2015年07期 　論文類型：期刊論文

【摘要】：目的探討單用伏立康唑(VO)及VO序貫兩性霉素B(AMB)治療艾滋病(AIDS)合并馬爾尼菲青霉菌病(PSM)的療效與安全性。方法前瞻性觀察36例確診AIDS合并PSM病人,單用VO及VO序貫AMB方案治療后的療效及不良反應(yīng)。結(jié)果 36例病人中,男性28例,女性8例,平均年齡34.5歲。血和骨髓培養(yǎng)均發(fā)現(xiàn)馬爾尼菲青霉菌(PM),抗真菌前83.3%存在肝功能受損,41.67%存在腎功能損害,50.0%發(fā)生嚴(yán)重貧血,19.4%外周血白細(xì)胞≤3×109/L,27.8%血小板≤50×109/L。初始治療使用VO,治療14天后復(fù)查血和骨髓培養(yǎng)PM情況:20例(55.6%)均轉(zhuǎn)陰,16例(44.4%)仍陽性。復(fù)查PM轉(zhuǎn)陰者繼續(xù)使用VO,陽性者則改用AMB。36例病人使用VO 14天后臨床癥狀好轉(zhuǎn),肝腎功能、血常規(guī)及血清鉀改善(P0.05),未出現(xiàn)嚴(yán)重藥物不良反應(yīng)。16例序貫治療病人使用AMB 14天后,血和骨髓培養(yǎng)均轉(zhuǎn)陰,肝腎功能、血常規(guī)及血清鉀無明顯變化(P0.05),未發(fā)生明顯不良反應(yīng)。結(jié)論 VO治療AIDS合并PSM多器官損害病人具有較好的療效和安全性,并能改善病人一般情況,為進(jìn)一步使用AMB根除PM創(chuàng)造機(jī)會(huì)。
[Abstract]:Objective to investigate the efficacy and safety of Volconazole (VOO) and VO sequential amphotericin (VO) in the treatment of AIDS with PSM. Results among 36 patients, 28 were male and 8 were female. The average age was 34. 5 years old. Blood and bone marrow culture showed that Penicillium marneffei was found to have liver function damage in 83.3% and liver function was impaired in 41.67% of patients with severe anemia. 19.4percent of peripheral blood leukocytes 鈮，

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