本文關(guān)鍵詞： 流行性腦脊髓膜炎 爆發(fā) C群腦膜炎奈瑟菌 多位點(diǎn)序列分型　出處：《中國疫苗和免疫》2016年02期 　論文類型：期刊論文

【摘要】：目的報(bào)告一起學(xué)校流行性腦脊髓膜炎(流腦)爆發(fā)疫情的病原學(xué)特征。方法對疑似流腦病例進(jìn)行流行病學(xué)調(diào)查,采集患者腦脊液和血標(biāo)本及首例病例密切接觸者咽拭子標(biāo)本,進(jìn)行病原學(xué)分離鑒定、實(shí)時(shí)熒光定量聚合酶鏈反應(yīng)(Polymerase Chain Reaction,PCR)檢測和多位點(diǎn)序列分型(Multi-locus Sequence Typing,MLST)分析。結(jié)果該起流腦爆發(fā)疫情由C群腦膜炎奈瑟菌引起,MLST分型為ST-4821高致病克隆群。結(jié)論該起疫情由C群腦膜炎奈瑟菌ST-4281引起,該克隆群為中國獨(dú)有的高致病基因群,本結(jié)果有利于制定全省流腦防控策略。
[Abstract]:Objective to report the etiological characteristics of a school epidemic cerebrospinal meningitis (meningitis) outbreak. Methods Epidemiological investigation was carried out on suspected cases of meningitis, and samples of cerebrospinal fluid and blood and pharynx swabs of the first case in close contact were collected. Pathogenic isolation and identification, Real-time fluorescence quantitative polymerase chain reaction (PCR) detection of Polymerase Chain reaction (PCR) and multilocus Sequence typing (MLSTs) analysis showed that the outbreak was caused by Neisseria meningitidis group C, which was classified as a highly pathogenic clone of ST-4821. Caused by Neisseria meningitidis group C ST-4281, The clone was a highly pathogenic gene group unique to China, and the results were helpful for the formulation of strategies for the prevention and control of cerebrospinal meningitis in the whole province.
【作者單位】： 貴州省疾病預(yù)防控制中心;黔西南州疾病預(yù)防控制中心;
【基金】：貴州省科學(xué)技術(shù)基金(黔科合J字[2014]2106號(hào))
【分類號(hào)】：R515.2
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本文編號(hào)：1512543