本文關(guān)鍵詞： 彝族人群 艾滋病病毒 耐藥性　出處：《中國艾滋病性病》2015年01期 　論文類型：期刊論文

【摘要】：目的分析涼山州部分彝族人群2011年艾滋病病毒1型(HIV-I)在未治療的感染人群中耐藥毒株變異情況,為指導(dǎo)抗病毒治療、評價治療效果、合理調(diào)整治療方案和制定應(yīng)對措施提供依據(jù)。方法對129例25歲以下新確診的HIV陽性血清樣本,用In-house方法進(jìn)行基因型耐藥檢測。共91例擴(kuò)增測序成功,檢測耐藥傳播相關(guān)的耐藥突變,并分析其相關(guān)的亞型及其比例。結(jié)果 91例樣本中,沒有針對PR區(qū)的主要耐藥性基因突變,但有7例樣本存在針對RT區(qū)耐藥性基因突變,4例為交叉突變(T215Y和V179E),3例為單一突變(T215Y、V179D和P225H),導(dǎo)致對齊多夫定(AZT)和司坦夫定(D4T)不同程度的耐藥。RT區(qū)耐藥株流行率為5.43%(7/129),屬于中等流行水平(5%~15%)。91例樣本中,CRF07-BCⅡ型所比例最大,達(dá)91.21%(83/91),B亞型僅占8.79%(8/91)。結(jié)論涼山州部分彝族人群未經(jīng)抗病毒治療的新發(fā)現(xiàn)HIV-1感染者中,已出現(xiàn)pol區(qū)耐藥突變株,且傳播水平達(dá)中度流行狀態(tài),需進(jìn)一步加強(qiáng)抗病毒治療患者的用藥督導(dǎo),提高其用藥依從性,并持續(xù)性監(jiān)測該地區(qū)抗病毒治療人群的耐藥情況。
[Abstract]:Objective to analyze the variation of drug-resistant strains of HIV type 1 (HIV-1) in untreated infected population in 2011 in some Yi people in Liangshan prefecture, so as to guide the antiviral therapy and evaluate the therapeutic effect. Methods A total of 129 newly diagnosed HIV positive serum samples under 25 years of age were tested for genotype resistance by In-house method. 91 cases were successfully amplified and sequenced. Drug resistance mutations associated with drug resistance transmission were detected, and the related subtypes and their proportions were analyzed. Results there were no major drug resistance gene mutations targeted to PR region in 91 samples. However, there were 7 cases of resistance gene mutation in RT region. 4 cases were cross-mutated T215Y and 3 cases were single mutation T215YN V179D and P225HG, which resulted in resistance to azidovudine AZT and Staveldine D4T in different degree. The prevalence rate of resistant strains in RT region was 5.437r129G. The proportion of CRF07-BC 鈪，

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