本文關(guān)鍵詞： 中性粒細(xì)胞 淋巴細(xì)胞 紅細(xì)胞分布寬度 肝炎 乙型肝炎　出處：《山東醫(yī)藥》2015年35期 　論文類型：期刊論文

【摘要】：目的觀察乙型肝炎患者外周血中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)、紅細(xì)胞分布寬度(RDW)變化,并探討其意義。方法 82例乙型肝炎患者按病情分為慢性乙型肝炎患者42例(A組)、慢性重型肝炎患者40例[B組,根據(jù)B組患者的NLR中位數(shù)(3.51)分為B1組(NLR≤3.51)和B2組(NLR3.51)各20例],另選45例健康體檢者作為對照(C組)。使用希森美康XE-5000型血常規(guī)分析儀檢測各組外周血中紅細(xì)胞(RBC)、血紅蛋白(Hb)、RDW、中性粒細(xì)胞的絕對數(shù)目和淋巴細(xì)胞的絕對數(shù)目,計算NLR。使用法國STAGO全自動血凝儀,采用凝固法檢測凝血酶原活動度(PTA)。結(jié)果與C組比較,A組RDW升高,RBC、Hb降低(P均0.05);與C組比較,B組RDW、NLR升高,RBC、Hb降低(P均0.05);與A組比較,B組RDW、NLR升高,PTA、RBC、Hb降低(P均0.05)。82例乙型肝炎患者中PTA與NLR呈負(fù)相關(guān)(r=-0.5571,P0.5)。與B2組比較,B1組NLR降低,年齡減小(P均0.05)。結(jié)論乙型肝炎患者NLR、RDW升高,檢測兩指標(biāo)有助于肝病病情嚴(yán)重程度和肝臟損害程度的判斷。
[Abstract]:Objective to observe the changes of the ratio of neutrophils to lymphocytes in peripheral blood of patients with hepatitis B and the RDW of erythrocyte distribution. Methods 82 patients with hepatitis B were divided into two groups: group A (n = 42) and group A (n = 40). [Group B, according to the median NLR of group B (3.51), was divided into B1 group (20 cases) and B2 group (20 cases). Another 45 healthy persons were selected as control group C, RDW of RBC and HB in peripheral blood of each group were detected by Xishenmekang XE-5000 blood routine analyzer. The absolute number of neutrophils and the absolute number of lymphocytes were calculated using the French STAGO automatic hemagglutination apparatus. The activity of prothrombin was detected by coagulation method. Results compared with group C, RDW increased in group A and HB decreased in both groups (P 0.05). Compared with group C, RDWN NLR in group B increased and HB decreased in group B (P < 0.05). Compared with group A, RDWN NLR in group B was higher than that in group A (P < 0.05). There was a negative correlation between PTA and NLR in 82 patients with hepatitis B. Compared with B2 group, NLR in group B _ 1 was lower than that in group B _ 2. Conclusion the RDW of NLRG in patients with hepatitis B is higher than that in the control group. The detection of the two indexes is helpful to judge the severity of liver disease and the degree of liver damage.
【作者單位】： 廣州市中山大學(xué)附屬第三醫(yī)院;
【基金】：教育部第44批留學(xué)回國人員科研啟動基金[教外司留(2012)9401]
【分類號】：R512.62
【正文快照】： 人類乙型肝炎病毒屬于肝DNA病毒科,正嗜肝病毒屬。全球約20億人曾感染過乙肝病毒(HBV),其中3.5億人為慢性HBV感染者,每年約有100萬人死于HBV感染所致的肝衰竭、肝硬化和原發(fā)性肝細(xì)胞癌[1]。我國屬HBV感染的高流行區(qū),慢性乙型肝炎是我國常見的慢性傳染病之一[2]。中性粒細(xì)胞與

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