Atoh1屬于bHLH轉(zhuǎn)錄因子家族成員,其對(duì)耳蝸毛細(xì)胞的胚胎發(fā)育及損傷后再生具有重要作用。許多訊號(hào)通道在轉(zhuǎn)錄水平上對(duì)Atoh1有調(diào)節(jié)作用,包括Notch和Wnt通道。在蛋白轉(zhuǎn)譯后水平,Atoh1是經(jīng)由泛素-蛋白酶通道所調(diào)節(jié)。體外細(xì)胞實(shí)驗(yàn)及體內(nèi)動(dòng)物實(shí)驗(yàn)都顯示:經(jīng)由上述訊號(hào)通道的調(diào)節(jié)手段不僅影響耳蝸發(fā)育,也導(dǎo)致毛細(xì)胞的損傷后再生。本綜述回顧了耳蝸內(nèi)各個(gè)對(duì)Atoh1調(diào)節(jié)訊號(hào)通道研究的進(jìn)展,并聚焦于泛素-蛋白酶通道對(duì)Atoh1進(jìn)行轉(zhuǎn)譯后調(diào)節(jié)及其對(duì)毛細(xì)胞發(fā)育的影響。 

【文章來(lái)源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2019,20(02)

【文章頁(yè)數(shù)】：10 頁(yè)

【文章目錄】：
1 Introduction
2 Hearing imààpccai22rment`àca22
3 Atoh1, a b HLH transcription factor, is required for hair cell differentiation and regeneration after damage
4 Atoh1 level is critical for hair cell devel-opment and regeneration in mice
5 Atoh1 is widely expressed
6 Signaling pathways that regulate Atoh1
    6.1 Notch signaling pathway
    6.2 Wnt/β-catenin signaling pathway
    6.3 Post-translational regulation of Atoh1:the CK1-Huwe1-ubiquitin-proteasome pathway
7 Concluding remarks
Compliance with ethics guidelines



本文編號(hào)：3062544