【摘要】：人白細胞相關(guān)免疫球蛋白樣受體1(leukocyte-associated immunoglobulin-like receptor-1，LAIR-1)是1997年基因克隆成功的分子，在2004年底舉行的第八屆國際人類白細胞分化抗原大會上獲準(zhǔn)了新的CD編號(CD305)。自從1983年發(fā)現(xiàn)該分子以來，已證明其是與免疫功能密切相關(guān)的抑制性受體，能夠抑制多種免疫細胞的功能。研究發(fā)現(xiàn)，LAIR-1具有廣泛的組織分布，并在造血細胞的分化、增殖中起重要的調(diào)節(jié)作用，是一個具有重要生物學(xué)功能及臨床潛在應(yīng)用前景的分子。 小鼠LAIR-1(murine LAIR-1，mLAIR-1)是人LAIR-1(human LAIR-1，hLAIR-1)基因在小鼠體內(nèi)的同源物，其序列在氨基酸水平與人LAIR-1分子有40％同源性，2002年我室首次從小鼠胸腺中成功克隆該基因(GenBankAF479685)。小鼠LAIR-1基因位于小鼠7號染色體上，共編碼263個氨基酸，，胞膜外區(qū)也含有1個免疫球蛋白(Ig)樣結(jié)構(gòu)域，故屬于免疫球蛋白超家族(IgSF)成員，胞質(zhì)區(qū)含有2個ITIM(immunoreceptor tyrosine-based inhibitory motif)樣基序。探討LAIR-1在人與鼠表達的異同點，有助于對該分子生物學(xué)功能的進一步認識，也有助于了解其在生物進化過程中所發(fā)生的變化。本博士論文是基于hLAIR-1分子研究的基礎(chǔ)上，對mLAIR-1分子的表達、分布及
[Abstract]:Human leukocyte-associated immunoglobulin-like receptor 1 (leukocyte-associated immunoglobulin-like receptor-1,LAIR-1) was successfully cloned in 1997. The new CD number (CD305) was approved at the eighth International Conference on Human Leukocyte differentiation Antigen, held at the end of 2004. Since its discovery in 1983, it has been proved to be an inhibitory receptor closely related to immune function, which can inhibit the functions of many immune cells. It has been found that LAIR-1 has a wide range of tissue distribution and plays an important role in regulating the differentiation and proliferation of hematopoietic cells. It is a molecule with important biological function and potential clinical application. Mouse LAIR-1 (murine LAIR-1,mLAIR-1) is a homologue of human LAIR-1 (human LAIR-1,hLAIR-1) gene in mice, and its sequence has 40% homology with human LAIR-1 at amino acid level. This gene (GenBankAF479685) was cloned successfully from mouse thymus for the first time in 2002. Mouse LAIR-1 gene, located on mouse chromosome 7, encodes a total of 263amino acids, and the extracellular domain also contains an immunoglobulin (Ig)-like domain, so it belongs to the (IgSF) member of immunoglobulin superfamily. The cytoplasmic region contained two ITIM (immunoreceptor tyrosine-based inhibitory motif)-like motifs. Discussing the similarities and differences of the expression of LAIR-1 in human and mouse is helpful to further understand the biological function of the molecule and to understand the changes of the molecular biological function in the process of biological evolution. This doctoral thesis is based on the study of hLAIR-1 molecules, the expression, distribution and distribution of mLAIR-1 molecules
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2006
【分類號】：R392

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相關(guān)期刊論文 前4條

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