【摘要】： 本文運(yùn)用傳統(tǒng)理論研究與現(xiàn)代實(shí)驗(yàn)研究相結(jié)合的方法，對(duì)“慢性阻塞性肺疾病(COPD)寒飲蘊(yùn)肺證”進(jìn)行了深入的理論探討和嚴(yán)謹(jǐn)?shù)膶?shí)驗(yàn)研究，旨在揭示寒飲蘊(yùn)肺證在具體疾病中的病變機(jī)理。在理論研究方面，主要探討了肺陽(yáng)在肺主行水中的作用，以及肺陽(yáng)虛導(dǎo)致肺失宣降，肺主行水功能失調(diào)，水飲停聚于肺，水為陰邪，肺陽(yáng)本虛，溫煦不足，，從而水飲寒化，形成寒飲蘊(yùn)肺之證。COPD作為呼吸系統(tǒng)的一種常見病，在中醫(yī)學(xué)中屬于咳嗽、喘證、肺脹等范疇，所以治療COPD寒飲蘊(yùn)肺證以溫肺陽(yáng)，補(bǔ)肺氣，祛寒飲為主。 為深化對(duì)“寒飲蘊(yùn)肺”的認(rèn)識(shí)，進(jìn)一步明確其微觀機(jī)制，本文在理論探討的基礎(chǔ)上，運(yùn)用當(dāng)前病證結(jié)合的造模理論，結(jié)合中醫(yī)傳統(tǒng)病因和現(xiàn)代醫(yī)學(xué)病理造模方法，成功復(fù)制了COPD寒飲蘊(yùn)肺證大鼠模型。本模型的復(fù)制方法綜合了病和證的研制方法，運(yùn)用了與COPD寒飲蘊(yùn)肺證的形成關(guān)系更為密切的多種因素，更加符合COPD寒飲蘊(yùn)肺證形成的條件和病機(jī)。借助小動(dòng)物肺功能儀、放免測(cè)定、免疫組化等技術(shù)，以多途徑、多指標(biāo)、同步觀察的方法，對(duì)造模動(dòng)物進(jìn)行了實(shí)驗(yàn)觀察及藥物干預(yù)，在癥狀表現(xiàn)方面，基本符合該病證的臨床表現(xiàn)，微觀指標(biāo)如肺組織病理形態(tài)學(xué)、肺功能、cAMP、cGMP等結(jié)果基本符合病COPD及以虛寒證為主的病證表現(xiàn)；用藥干預(yù)組的檢測(cè)指標(biāo)有明顯改善，從而證明了模型的可靠性。為肺藏象的現(xiàn)代研究及中醫(yī)辨證的客觀化提供了實(shí)驗(yàn)依據(jù)。
[Abstract]:Based on the combination of traditional theoretical research and modern experimental research, this paper makes a thorough theoretical study and rigorous experimental study on "(COPD) cold drink accumulation of lung syndrome" in chronic obstructive pulmonary disease (COPD). The purpose of this study was to reveal the pathological mechanism of cold-drink syndrome of lung accumulation in specific diseases. In the theoretical research, it mainly discusses the role of lung yang in the lung water, as well as the deficiency of lung yang leading to the loss of the lung, the imbalance of the function of the lung, the water drinking stops in the lung, the water is Yin evil, the deficiency of the lung yang is the deficiency of the lung yang, and the warmth is insufficient, so that the water drinks cold. COPD, as a common disease of respiratory system, belongs to the category of cough, asthma and lung distension in traditional Chinese medicine, so the treatment of COPD cold drink accumulation lung syndrome is mainly to warm the lung yang, tonify the lung qi, and dispel cold drink. In order to deepen the understanding of "cold drink to accumulate the lung" and to further clarify its microscopic mechanism, this paper, on the basis of theoretical discussion, applies the current model making theory of combining disease and syndrome, combining the traditional etiology of traditional Chinese medicine and modern medical pathological modeling method. The rat model of COPD cold drink accumulation of lung syndrome was successfully duplicated. The replication method of this model synthesizes the development method of disease and syndrome, and uses many factors which are more closely related to the formation of COPD cold drink accumulation lung syndrome, which is more in line with the conditions and pathogenesis of the formation of COPD cold drink accumulation lung syndrome. With the help of small animal lung function instrument, radioimmunoassay, immunohistochemistry and other techniques, the animal model was observed and drug intervention was carried out with the methods of multi-channel, multi-index and synchronous observation. The results of microscopic indexes such as lung histopathology, pulmonary function and cAMP,cGMP basically accord with the clinical manifestations of the disease and the symptoms of deficiency and cold syndrome. The test indexes of the intervention group were improved obviously, which proved the reliability of the model. It provides the experimental basis for the modern study of lung storage and the objectification of TCM syndrome differentiation.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2006
【分類號(hào)】：R-332

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 孫廣仁;鞏會(huì)利;高博;張哲;;寒涼因素在慢性阻塞性肺疾病寒飲蘊(yùn)肺證大鼠模型形成中的作用[J];山東中醫(yī)藥大學(xué)學(xué)報(bào);2011年04期

相關(guān)碩士學(xué)位論文 前2條

1 劉瀚陽(yáng);溫陽(yáng)化飲方和甘草干姜湯對(duì)慢性阻塞性肺疾病寒飲蘊(yùn)肺證大鼠模型干預(yù)的比較性研究[D];山東中醫(yī)藥大學(xué);2011年

2 薛武更;慢性阻塞性肺疾病寒飲蘊(yùn)肺證大鼠模型的評(píng)價(jià)[D];山東中醫(yī)藥大學(xué);2007年

本文編號(hào)：2383362