【摘要】：目的構(gòu)建支氣管肺發(fā)育不良新生大鼠模型。方法將30只3日齡雄性wistar大鼠隨機(jī)分為兩組各15只,高氧組置于氧箱(氧濃度60%),對照組置于空氣(氧濃度21%),分別于實(shí)驗第7、14、21天取大鼠肺組織觀察組織病理及膠原含量變化。結(jié)果高氧組肺泡結(jié)構(gòu)消失、肺泡間隔增厚、肺泡融合;肺Ⅰ、Ⅲ型膠原面積顯著增加(P0.001)。結(jié)論較高濃度氧持續(xù)吸入可致新生鼠肺部產(chǎn)生類似人支氣管肺發(fā)育不良的組織改變。
[Abstract]:Objective to establish a neonatal rat model of bronchopulmonary dysplasia. Methods Thirty 3-day-old male wistar rats were randomly divided into two groups, 15 rats in each group. The hyperoxia group was placed in the oxygen box (oxygen concentration 60%) and the control group in the air (oxygen concentration 21%). The histopathology and collagen content were observed in the lung tissue of rats on day 7, 14 and 21, respectively. Results in the hyperoxia group, the alveolar structure disappeared, the alveolar septum thickened, the alveolar fusion and the area of type 鈪，

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