【摘要】： 隨著社會的進步,對骨質(zhì)疏松癥的預(yù)防和治療越來越得到重視,國內(nèi)外學(xué)者對預(yù)防和治療骨質(zhì)疏松做了大量的研究,但是研究去勢骨質(zhì)疏松以中藥、西藥、電磁針、VD、雌激素防治骨質(zhì)疏松骨骼的骨密度,骨骼的拉伸、壓縮、彎曲、扭轉(zhuǎn)、剪切、沖擊力學(xué)性質(zhì)和應(yīng)力松弛、蠕變粘彈性(流變)性質(zhì)。及研究去勢骨質(zhì)疏松以中藥、西藥等治療動物血液的血磷、血鈣、堿性磷酸酶指標(biāo)、動物骨組織的顯微結(jié)構(gòu)改變情況未見報道。 鑒于相關(guān)研究和臨床需要,作者設(shè)計了一組實驗,將350只雌性大鼠隨機分成正常對照組、模型組、中藥治療組、西藥治療組、電磁針治療組、雌激素治療組、VD治療組。各組大鼠飼養(yǎng)第十五周周末在腹主動脈采血,取血清用于血磷、血鈣和堿性磷酸酶測定,之后處死大鼠。取各組大鼠L3、L4、L5椎骨測量骨密度,取各組大鼠股骨粗隆部進行組織學(xué)觀察;取各組大鼠骨進行拉伸實驗;取各組大鼠骨進行壓縮實驗;取各組大鼠骨進行彎曲實驗;取各組大鼠骨進行扭轉(zhuǎn)實驗;取各組大鼠骨進行剪切實驗;取各組大鼠骨進行沖擊實驗;取各組大鼠骨進行應(yīng)力松弛實驗;取各組大鼠骨進行蠕變實驗。 得出了各組大鼠骨密度、血清中血磷、血磷、堿性磷酸酶等生化指標(biāo)。得出了各組大鼠骨顯微結(jié)構(gòu)分析結(jié)果。得出了各組大鼠骨拉伸、壓縮、彎曲、應(yīng)力、應(yīng)變、彈性模量等數(shù)據(jù)。得出了各組大鼠骨扭轉(zhuǎn)剪應(yīng)力、扭矩、扭轉(zhuǎn)角數(shù)據(jù),得出各組大鼠骨骼沖擊功、沖擊韌性數(shù)據(jù)。得出了各組大鼠骨骼5400S應(yīng)力松弛量、蠕變量,得出了各組大鼠骨骼歸一化應(yīng)力松弛函數(shù),歸一化蠕變函數(shù),以期為骨質(zhì)疏松的研究和臨床提供理論基礎(chǔ)。
[Abstract]:With the progress of society, more and more attention has been paid to the prevention and treatment of osteoporosis. Scholars at home and abroad have done a lot of research on the prevention and treatment of osteoporosis, but the study of ovariectomized osteoporosis by Chinese medicine, western medicine, electromagnetic acupuncture, VD, Estrogen prevents bone mineral density (BMD), bone stretching, compression, bending, torsion, shear, impact and stress relaxation, creep viscoelastic (rheological) properties. There was no report on the changes of blood phosphorus, calcium, alkaline phosphatase and bone microstructure of ovariectomized osteoporosis treated with traditional Chinese medicine and western medicine. In view of the relevant research and clinical needs, the author designed an experiment in which 350 female rats were randomly divided into normal control group, model group, traditional Chinese medicine treatment group, western medicine treatment group, electromagnetic acupuncture group, estrogen treatment group and VD treatment group. Blood samples were collected from abdominal aorta at the end of the fifteenth week of feeding in each group. Serum was collected for determination of serum phosphorus, calcium and alkaline phosphatase, and then the rats were killed. The bone mineral density (BMD) was measured by L3, L4, L5 vertebrae, the femoral trochanter of each group was observed histologically, the bone of each group was taken for stretching test, the bone of each group was compressed, the bone of each group was obtained for bending test. Every group of rat bone for torsion test; each group of rat bone for shear test; each group of rat bone for impact test; each group of rat bone for stress relaxation test; each group of rat bone for creep test. The biochemical indexes of bone mineral density, serum phosphorus and alkaline phosphatase were obtained. The results of bone microstructure analysis in each group were obtained. The data of bone stretching, compression, bending, stress, strain and elastic modulus were obtained. The data of bone torsion shear stress, torque and torsion angle were obtained, and the data of bone impact work and impact toughness were obtained. The stress relaxation quantity and creep amount of rat bone 5400S in each group were obtained. The normalized stress relaxation function and the normalized creep function were obtained in each group of rats in order to provide a theoretical basis for the study and clinical application of osteoporosis.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2007
【分類號】：R580;R-332

【參考文獻】

相關(guān)期刊論文 前10條

1 王東巖,蔡紅,卓鐵軍;針刺背俞穴對原發(fā)性骨質(zhì)疏松癥腰椎骨密度的影響[J];安徽中醫(yī)臨床雜志;2001年01期

2 馬宗民,朱興華,朱偉民,麻文焱;婦女絕經(jīng)、老齡對骨質(zhì)疏松的影響[J];北京生物醫(yī)學(xué)工程;2005年05期

3 劉獻祥,吳炳煌,吳明霞,林薇,鄭良樸,林久茂,李俐;針灸對原發(fā)性骨質(zhì)疏松癥影響的實驗研究[J];福建中醫(yī)學(xué)院學(xué)報;2000年01期

4 吳明霞,吳炳煌,錢松濤,李俐,闕慶輝,林鵡,吳越,王艦;針灸對骨質(zhì)疏松患者骨密度作用的臨床研究[J];福建中醫(yī)學(xué)院學(xué)報;2000年04期

5 李梅,孟迅吾,周學(xué)瀛;Ⅰ型膠原蛋白與骨質(zhì)疏松癥研究進展[J];國外醫(yī)學(xué)(內(nèi)分泌學(xué)分冊);2000年01期

6 李曉佳,李雙慶,魏松全;骨質(zhì)量為骨質(zhì)疏松癥診治的新動向[J];國外醫(yī)學(xué).內(nèi)分泌學(xué)分冊;2001年03期

7 龔慧慈,劉海倫;骨密度的遺傳學(xué)[J];國外醫(yī)學(xué)(內(nèi)分泌學(xué)分冊);2003年02期

8 熊芳麗,肖亞平;耳針治療中老年婦女骨質(zhì)疏松癥60例臨床觀察[J];貴陽中醫(yī)學(xué)院學(xué)報;2000年02期

9 郝永強,戴戴戎;實驗性骨質(zhì)疏松性骨折愈合方式的組織學(xué)觀察[J];上海醫(yī)學(xué);1999年03期

10 趙英俠,嚴(yán)振國,余安勝,邵水金,趙敏生;針灸對卵巢切除大鼠骨代謝的影響[J];上海針灸雜志;1999年05期

相關(guān)博士學(xué)位論文 前1條

1 李良;力學(xué)刺激對絕經(jīng)后骨質(zhì)疏松大鼠成骨細胞作用的細胞分子基礎(chǔ)[D];四川大學(xué);2004年

，

本文編號：2324048