發(fā)布時間：2018-11-05 17:44

【摘要】：目的:以生殖異�；颊呷旧w多態(tài)性的檢出率為主因素進行研究,探討染色體多態(tài)性與生殖異常之間的關系。方法:從2004年1月~2006年1月就診于吉大一院檢驗科及基礎醫(yī)學院生殖醫(yī)學化驗室進行細胞遺傳學檢查的患者中篩選229對生殖異常夫婦(包括妊娠胎兒丟失、不孕不育及有缺陷兒出生)作G顯帶染色體核型分析。結果:1. 229對生殖異常夫婦中染色體多態(tài)性變異檢出率為10.7%,明顯高于普通人群中的發(fā)生率(P0.05);男女比例為8.8:1,相差懸殊。2. 1、9、16號染色體次縊痕增加檢出率為1.5%,inv(9)檢出率為0.4%,大Y檢出率為7.6%,D/G組染色體短臂延長檢出率為1.1%。3.妊娠胎兒丟失、不孕不育、有缺陷兒出生等生殖異常患者染色體多態(tài)性變異檢出率均明顯高于普通人群中的發(fā)生率(P0.05)。4.胎兒丟失發(fā)生于妊娠早期者染色體多態(tài)性變異檢出率高于胎兒丟失發(fā)生于妊娠中、晚期者的檢出率(P0.05),而后兩者的檢出率之間無統(tǒng)計學差異(P0.05)。5.異常孕產(chǎn)≥3次者染色體多態(tài)性變異檢出率均高于異常孕產(chǎn)1次和2次者的檢出率(P0.05),而后兩者的檢出率之間無統(tǒng)計學差異(P0.05)。結論:染色體多態(tài)性與生殖異常具有相關性,且大多影響胚胎發(fā)育的早期階段,隨著異常孕產(chǎn)次數(shù)增加,夫婦一方染色體多態(tài)性變異比率有相應增高的趨勢。
[Abstract]:Objective: to investigate the relationship between chromosome polymorphism and reproductive abnormality. Methods: from January 2004 to January 2006, 229 couples with abnormal reproduction (including the loss of pregnancy fetus) were selected from the laboratory of reproductive medicine and the laboratory of reproductive medicine of the first Hospital of Jida for cytogenetic examination. The karyotype of G-banded chromosomes was analyzed. The result is 1: 1. The detection rate of chromosome polymorphisms in 229 couples with abnormal reproduction was 10.7, which was significantly higher than that in the general population (P0.05), and the ratio of male to female was 8.88: 1, the difference was significant. 2. The increase rate of chromosome 1, chromosome 9 and chromosome 16 was 1.5%. The detection rate of small Y was 0.4 and the detection rate of large Y was 7.6%. The detection rate of short arm lengthening was 1.1% and 1.3% respectively. The detection rate of chromosomal polymorphisms in pregnant women with fetal loss, infertility and birth defects was significantly higher than that in the general population (P0.05). The detection rate of chromosomal polymorphisms in early pregnancy was higher than that in late pregnancy (P0.05), but there was no significant difference between the latter two (P0.05). The detection rate of chromosome polymorphism in abnormal pregnancy 鈮，

本文編號：2312832