【摘要】：背景和目的： 由于臨床研究受多種因素干擾，深入研究心臟驟停(Caridac arrest，CA)和心肺復(fù)蘇(Cardiopulmonary resuscitation，CPR)的病理生理機(jī)制受到一定限制。動物實驗的優(yōu)勢之一是能夠嚴(yán)格控制各種混雜因素，使實驗結(jié)果具有重復(fù)性，為研究疾病的發(fā)生機(jī)制、驗證各種治療藥物或治療手段創(chuàng)造了條件。由于小動物(如家兔、大鼠和小鼠等)的許多生理特性與大動物、甚至人類非常相似，采用小動物進(jìn)行CPR的實驗研究已經(jīng)引起人們的廣泛重視。 建立CA動物模型是進(jìn)行CPR研究的前提條件。用交流電經(jīng)右心室心內(nèi)膜電擊誘導(dǎo)大鼠和小鼠發(fā)生室顫是目前建立CA動物模型的主要方法。由于操作復(fù)雜，其應(yīng)用受到限制。本研究的目的之一是尋找較為簡便的、復(fù)制小動物室顫模型的方法。 心臟起搏在緩慢型心律失常的治療中具有肯定的療效，但在CPR中是否有效仍有爭議。本研究的目的之二是觀察經(jīng)食道心臟起搏在窒息性CA大鼠CPR中的療效，，探討其作用機(jī)制和影響因素。 藥物在CPR中起重要作用。由于納絡(luò)酮和加壓素在CPR中的療效仍有爭議，不同劑量的腎上腺素在大鼠CPR中的療效如何尚未見有文獻(xiàn)報導(dǎo)。本研究的目的之三是觀察納絡(luò)酮和加壓素在窒息性CA動物模型中的療效，以及不同劑量加壓素與腎上腺素對復(fù)蘇療效的影響，并對神經(jīng)內(nèi)分泌系統(tǒng)的變化與CPR療效的關(guān)系進(jìn)行探討。
[Abstract]:Background and objective: the study of pathophysiological mechanism of cardiac arrest (Caridac arrest,CA) and cardiopulmonary resuscitation (Cardiopulmonary resuscitation,CPR) is limited by many factors. One of the advantages of animal experiments is that they can strictly control all kinds of confounding factors and make the experimental results repeatable, thus creating conditions for studying the mechanism of disease and verifying various therapeutic drugs or treatment methods. Because many physiological characteristics of small animals (such as rabbits, rats and mice) are very similar to those of large animals and even humans, the experimental study of using small animals to carry out CPR has been paid more and more attention. The establishment of CA animal model is a prerequisite for CPR research. Ventricular fibrillation in rats and mice induced by right ventricular endocardial electric shock by alternating current is the main method to establish CA animal model. Because of the complex operation, its application is limited. One of the purposes of this study is to find a simple and convenient method for replicating ventricular fibrillation in small animals. Cardiac pacing has a positive effect in the treatment of bradyarrhythmia, but whether it is effective in CPR remains controversial. The second purpose of this study was to observe the therapeutic effect of transesophageal cardiac pacing on asphyxiated CA rats CPR and to explore its mechanism and influencing factors. Drugs play an important role in CPR. As the efficacy of naloxone and vasopressin in CPR is still controversial, the effect of different doses of epinephrine on CPR in rats has not been reported. The third objective of this study was to observe the efficacy of naloxone and vasopressin in asphyxiated CA animal model and the effects of different doses of vasopressin and epinephrine on resuscitation. The relationship between the changes of neuroendocrine system and the curative effect of CPR was discussed.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2006
【分類號】：R-332;R720.597

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