【摘要】：結(jié)核病(Tuberculosis，TB)一直是嚴(yán)重威脅人類健康的以呼吸系統(tǒng)感染為主的慢性傳染性疾病，其病原菌是結(jié)核分枝桿菌(Mycobacteriumtuberculosis，MTB)。隨著AIDS的蔓延，原來(lái)曾被人類控制并有望在發(fā)達(dá)國(guó)家消失的結(jié)核病，其發(fā)病率和死亡率在許多國(guó)家和地區(qū)出現(xiàn)上升的趨勢(shì)。在過(guò)去的十年中，結(jié)核病成為人類死亡的重要原因。WHO報(bào)道，全球近三分之一的人已感染結(jié)核菌，每年有約八百萬(wàn)新結(jié)核病人出現(xiàn)，死亡的人數(shù)達(dá)兩百萬(wàn)人，如果結(jié)核菌感染得不到有效控制的話，從2002年到2020年，，又將有10億人感染結(jié)核菌。我國(guó)是世界上22個(gè)結(jié)核病高發(fā)國(guó)家之一，結(jié)核病人數(shù)居世界第二位，形勢(shì)嚴(yán)峻。這可能是由于人類免疫缺陷病毒(HIV)在全世界范圍的傳播，引起艾滋病的廣泛流行，機(jī)體免疫力下降甚至缺陷，進(jìn)而導(dǎo)致結(jié)核病的流行。全球范圍的移民和人口流動(dòng)使結(jié)核菌傳播范圍進(jìn)一步擴(kuò)大。再加上90％結(jié)核菌感染者為隱匿感染，阻礙了結(jié)核病的防治。結(jié)核菌診斷的金標(biāo)準(zhǔn)是結(jié)核菌的培養(yǎng)，而其生長(zhǎng)緩慢，如何使MTB快速生長(zhǎng)成為研究熱點(diǎn)之一。因此積極深入研究結(jié)核病的發(fā)病機(jī)制，找出更加有效的診斷、治療和預(yù)防結(jié)核病的新技術(shù)、新方法和新疫苗具有深遠(yuǎn)的意義。
[Abstract]:Tuberculosis (TB) is a chronic infectious disease which is a serious threat to human health. The main pathogen of tuberculosis is Mycobacterium tuberculosis (MTB). With the spread of AIDS, tuberculosis, once controlled by human beings and expected to disappear in developed countries, has an increasing trend of morbidity and mortality in many countries and regions. In the past decade, tuberculosis has become an important cause of human death. The WHO reports that nearly 1/3 people worldwide have been infected with TB, and about 8 million new TB patients appear each year, with 2 million deaths. If TB infection is not effectively controlled, another 1 billion people will be infected between 2002 and 2020. China is one of the 22 countries with high incidence of tuberculosis. This may be due to the spread of human immunodeficiency virus (HIV) in the world, causing the widespread spread of AIDS, the decline of immunity and even the deficiency of the body, which leads to the prevalence of tuberculosis. Worldwide migration and population mobility have further expanded the spread of tuberculous bacteria. In addition, 90% of TB infection is concealed infection, which hinders the prevention and treatment of tuberculosis. The gold standard for the diagnosis of tuberculous bacteria is the culture of tuberculous bacteria, but its growth is slow. How to make the rapid growth of MTB become one of the research hotspots. Therefore, it is of great significance to study the pathogenesis of tuberculosis, find out more effective diagnosis, treatment and prevention of tuberculosis new technology, new methods and new vaccines.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R346

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 周珊;HBHA在MTB感染AECⅡ過(guò)程中的作用研究[D];第四軍醫(yī)大學(xué);2010年

本文編號(hào)：2174426