本文選題：自身免疫性疾病　切入點(diǎn)：單核苷酸多態(tài)性　出處：《中國(guó)免疫學(xué)雜志》2014年01期

【摘要】：正自身免疫性疾病是機(jī)體對(duì)自身成分發(fā)生免疫應(yīng)答而導(dǎo)致的疾病狀態(tài),其基本特征是自身應(yīng)答性T淋巴細(xì)胞或自身抗體造成相應(yīng)的組織細(xì)胞損傷或功能障礙,血液中可檢測(cè)到高效價(jià)的自身應(yīng)答性T淋巴細(xì)胞和/或自身抗體,且病情的轉(zhuǎn)歸與自身免疫應(yīng)答的強(qiáng)度密切相關(guān)。T輔助細(xì)胞1型(T-helper cell type 1,Th1)、Th17細(xì)胞功能失調(diào)可誘導(dǎo)多種自身免疫性疾病的發(fā)生[1]。信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活子4(Signal transducer and
[Abstract]:Positive autoimmune disease is a state of disease caused by the body's immune response to its own components. Its basic characteristic is that autoresponsive T lymphocytes or autoantibodies cause corresponding tissue and cell damage or dysfunction. High titers of autoresponsive T lymphocytes and / or autoantibodies can be detected in the blood. And the outcome of the disease is closely related to the intensity of the autoimmune response. T-helper cell type 1 Th1 Th17 cell dysfunction can induce the occurrence of many autoimmune diseases [1]. Signal transduction and transcriptional activator 4(Signal transducer and
【作者單位】： 山西醫(yī)科大學(xué)第二醫(yī)院血液科;
【基金】：衛(wèi)生行業(yè)科研專項(xiàng)項(xiàng)目(No.200802031)資助
【分類號(hào)】：R392.2

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王銀君;鄭學(xué)寶;朱宇珍;呂汝西;;潰瘍性結(jié)腸炎基因單核苷酸多態(tài)性的研究進(jìn)展[J];廣東醫(yī)學(xué);2013年18期

2 龐智;鄭連民;尹少朋;皇甫照;施瑞華;;STAT4基因rs7574865多態(tài)性與中國(guó)漢族人群克羅恩病的相關(guān)性[J];南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版);2012年01期

3 鄭子安;鐘相根;賈旭;鄧秀蘭;王青青;張曉晶;王坦;;右歸丸對(duì)實(shí)驗(yàn)性自身免疫性腦脊柱炎小鼠IL-23/IL-17炎性軸的影響[J];遼寧中醫(yī)雜志;2013年10期

4 胡，

本文編號(hào)：1665958