本文選題：凍融胚胎移植　切入點：自然周期　出處：《河北醫(yī)科大學(xué)》2006年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：凍融胚胎移植作為輔助生殖技術(shù)的有效補充治療手段，日趨受到關(guān)注。凍融胚胎移植周期的子宮內(nèi)膜準(zhǔn)備方案，目前在臨床上主要有兩種：自然周期和激素替代周期。對于以上兩種方案對臨床妊娠率的影響國內(nèi)外學(xué)者的觀點仍不一致。因此，本研究旨在通過比較兩種方案對臨床妊娠率的影響，以指導(dǎo)臨床選擇較好的方案行凍融胚胎移植前子宮內(nèi)膜準(zhǔn)備。因凍融胚胎移植妊娠失敗大多發(fā)生在胚胎植入階段，所以子宮內(nèi)膜對胚胎的接受狀態(tài)成為目前研究的熱點。由于研究內(nèi)膜容受性的內(nèi)膜活檢和宮腔沖洗技術(shù)都有侵入性且對妊娠有消極影響，不宜用于凍融胚胎移植治療周期。已有許多研究證實細(xì)胞因子和生長因子在胚胎植入過程中起重要作用，例如白血病抑制因子(leukemia inhibitory factor，LIF)、表皮生長因子(epidermal growth factor，EGF)、巨噬細(xì)胞集落刺激因子(macrophage-colony stimulating factor，M-CSF)等。近來研究表明與胚胎植入相關(guān)的細(xì)胞因子和生長因子在生殖道分泌物中也可測出，這樣采集標(biāo)本所需技術(shù)的侵入性即可減小到最小程度。分泌物中所測得的細(xì)胞因子很可能來自子宮內(nèi)膜，而他們的表達(dá)也可能受控制內(nèi)膜分泌細(xì)胞因子的激素所調(diào)節(jié)。因此，本研究的另一個目的在于通過比較妊娠組與非妊娠組內(nèi)膜的超聲類型與厚度，血清雌二醇(estuarial，E_2)、孕激素(progesterone，P)、雌孕激素比值(estuarial progesterone ratio，E_2/P)，血清及宮頸分泌
[Abstract]:Objective: freezing and thawing embryo transfer as an effective supplementary therapy of assisted reproductive technology has attracted more and more attention. At present, there are two main clinical types: natural cycle and hormone replacement cycle. The purpose of this study was to compare the effects of two methods on the clinical pregnancy rate in order to guide the clinical choice of the better protocol for the preparation of endometrium before freeze-thawed embryo transfer. The failure of frozen and thawed embryo transfer pregnancy mostly occurred in the embryo implantation stage. Therefore, the status of endometrial acceptance of embryos has become a hot topic. Because endometrial biopsy and uterine cavity irrigation are both invasive and have a negative impact on pregnancy, It is not suitable for the treatment cycle of freeze-thawed embryo transfer. Many studies have proved that cytokines and growth factors play an important role in embryo implantation. For example, leukemia inhibitory factor, epidermal growth factor, macrophage colony stimulating factor, macrophage colony stimulating factor, and so on. Recent studies have shown that cytokines and growth factors associated with embryo implantation can also be detected in reproductive tract secretions. This minimizes the invasive nature of the techniques needed to collect the samples. The cytokines measured in the secretion are likely to come from the endometrium, and their expression may also be regulated by hormones that control the secretion of cytokines from the endometrium. Another purpose of this study was to compare the ultrasound types and thickness of endometrium between pregnancy group and non-pregnancy group, serum estradiol Estuary E2P, progesterone, estradiol / progesterone, ratio of estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradiol / estradi@@
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R321-33

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