本文選題：oddi括約肌　切入點(diǎn)：電生理　出處：《第三軍醫(yī)大學(xué)》2006年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】： oddi括約肌是位于膽胰管和十二指腸之間的特殊結(jié)構(gòu),它的發(fā)現(xiàn)和命名已經(jīng)有一百多年的歷史。然而到現(xiàn)在為止,很多起源于SO的疾病例如SOD的發(fā)病機(jī)制我們卻幾乎一無(wú)所知。對(duì)于大部分動(dòng)物SO不但體積小而且被包繞在十二指腸壁和胰腺內(nèi),這種解剖使其電生理的研究變得非常困難,用傳統(tǒng)方法測(cè)量SO肌電創(chuàng)傷大而且易受干擾,非常不穩(wěn)定,極大阻礙了對(duì)于SO生理功能的的研究和認(rèn)識(shí)。本課題的目的是建立一種新的SO肌電測(cè)量方法。 本課題分為兩部分內(nèi)容: 第一部分:家兔oddi括約肌肌電測(cè)量的新方法 目的:摸索適合家兔SO肌電測(cè)量的新方法 材料和方法:36只健康家兔,隨機(jī)選取30只家兔分為兩組,每組15只,分別為粘膜組  針對(duì)傳統(tǒng)針型漿膜電極創(chuàng)傷大,測(cè)量不穩(wěn)定的缺點(diǎn),嘗試制作通過(guò)粘膜接觸采集電活動(dòng)信號(hào)的電極,電極主體為外徑為1mm內(nèi)徑0.5mm的硅膠導(dǎo)管一根以及直徑約0.15mm銀絲兩根,沿膽管走行方向?qū)EM直接從乳頭插入并留置在SO段膽管腔內(nèi)。漿膜組  家兔采用CCE測(cè)量肌電活動(dòng),方法參照我中心前期研究。剩下6只家兔在通過(guò)CEM測(cè)量SO肌電的同時(shí)通過(guò)CCE同步測(cè)量SO肌電活動(dòng)。觀(guān)察指標(biāo)為SO鋒電位(Spike Potentials of SO,SPSO)以及SO肌電簇(Myoelectronic activity of SO,MASO)。 結(jié)果: 在21只使用CEM測(cè)量肌電的家兔中,全部滿(mǎn)意的測(cè)量到了SO肌電,波形穩(wěn)定,重復(fù)性好。在21只使用CCE測(cè)量肌電的家兔中,只有15只滿(mǎn)意的測(cè)量到了SO肌電。兩種方法同步測(cè)量觀(guān)察到的鋒電位有1:1的對(duì)應(yīng)關(guān)系,波形有明顯的同源性,波形特征基本一致。 第二部分:粘膜接觸式電極在犬oddi括約肌肌電測(cè)量中的應(yīng)用研究 目的:嘗試采用CEM測(cè)量犬SO肌電活動(dòng)并結(jié)合同步胃十二指腸肌電測(cè)量以及同步測(cè)壓對(duì)測(cè)量到的SO肌電波形進(jìn)行確認(rèn)和分析。
[Abstract]:The sphincter of oddi, a special structure between the biliary and pancreatic ducts and the duodenum, has been discovered and named for more than 100 years. We know little about the pathogenesis of many so-derived diseases, such as SOD. For most animals, so is not only small but also wrapped around the duodenum and pancreas, which makes it very difficult to study electrophysiology. The traditional method of measuring so electromyoelectric injury is very unstable, which greatly hinders the research and understanding of so physiological function. The purpose of this paper is to establish a new method of so electromyography measurement. This topic is divided into two parts:. Part I: a new method for measuring the electromyography of oddi sphincter in rabbits. Objective: to explore a new method for measuring so electromyography in rabbits. Materials and methods Thirty six healthy rabbits were randomly divided into two groups, 15 rabbits in each group. An electrode was made to collect electrical activity signals through mucosal contact. The main electrode was a silica gel tube with an outer diameter of 1 mm and a diameter of 0.5 mm, and two silver wires with a diameter of 0.15 mm. CEM was inserted directly from the papilla and placed in the so segment of bile duct along the direction of the bile duct. CCE was used to measure myoelectric activity in the serosal group. Methods according to the previous study in our center, the other 6 rabbits were used to measure so myoelectric activity by means of CEM and CCE simultaneously. The observed indexes were so spike Potentials of SOS and so myoelectric cluster Myoelectronic activity of SOMASOA. Results:. Among the 21 rabbits using CEM to measure EMG, all of them were satisfied with so EMG, the waveforms were stable and reproducible. In 21 rabbits, CCE was used to measure EMG. Only 15 of them were satisfied with so electromyoelectricity. The peak potential measured simultaneously by the two methods had a corresponding relation of 1: 1, the waveform had obvious homology, and the waveform characteristics were basically the same. The second part: the application of mucosal contact electrode in the electromyography of oddi sphincter in dogs. Objective: to determine and analyze the so myoelectric activity in dogs by using CEM and simultaneous gastroduodenal electromyography (EMG) measurement and simultaneous pressure measurement.
【學(xué)位授予單位】：第三軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類(lèi)號(hào)】：R33

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