【摘要】：目的： 為致傷后較長時(shí)間的觀察單純腹壁爆炸傷合并內(nèi)臟器官外露的傷情，研究此類創(chuàng)傷的致傷和轉(zhuǎn)歸規(guī)律，，建立一種能在致傷后較長時(shí)間存活的單純腹壁爆炸傷合并內(nèi)臟器官外露的動(dòng)物模型。 方法： 8-10周齡，生長期白家兔12只，隨機(jī)分為2組，每組6只。在全身麻醉?xiàng)l件下，預(yù)先備皮標(biāo)記致傷部位。實(shí)驗(yàn)組采用自制腹腔防護(hù)裝置置入腹腔，然后采用0.125gTNT當(dāng)量炸藥球貼于致傷部位致傷；對照組不防護(hù)處理直接采用同樣爆源致傷。傷后觀察各組實(shí)驗(yàn)動(dòng)物大體形態(tài)，對活體動(dòng)物每日取傷部組織行病理切片觀察，對死亡動(dòng)物記錄生存時(shí)間并行尸檢。 結(jié)果： 兩組動(dòng)物致傷部位腹壁均呈全層開放性爆炸傷。實(shí)驗(yàn)組實(shí)驗(yàn)動(dòng)物創(chuàng)面面積為3.8±0.56cm2；對照組創(chuàng)傷面積為3.93±0.49cm2。P0.05兩組間并無顯著差異。實(shí)驗(yàn)組實(shí)驗(yàn)動(dòng)物存活時(shí)間為142±87.78h。對照組實(shí)驗(yàn)動(dòng)物平均存活時(shí)間為3.77±2.25h。P0.05。兩組動(dòng)物存活時(shí)間存在明顯差異。實(shí)驗(yàn)組明顯長于對照組。尸檢和病理觀察發(fā)現(xiàn)，對照組動(dòng)物早期死亡原因?yàn)楦骨粌?nèi)出血和內(nèi)臟損傷，實(shí)驗(yàn)組則發(fā)生內(nèi)臟纖維粘連，但未見明顯內(nèi)臟創(chuàng)傷。病理組織切片觀察發(fā)現(xiàn)，腹壁各層組織受爆炸創(chuàng)傷有差異，呈現(xiàn)“外輕內(nèi)重”的病理變化，并進(jìn)行性發(fā)展，肌肉組織的變化最為典型。 結(jié)論： 本實(shí)驗(yàn)?zāi)M了單純腹壁爆炸傷合并內(nèi)臟器官外露的致傷機(jī)制。經(jīng)有效防護(hù)，建立了致傷后存活時(shí)間較長的單純腹壁爆炸傷動(dòng)物模型。
[Abstract]:Objective: in order to observe the injury condition of abdominal wall explosion injury complicated with visceral organ exposure for a long time after injury, to study the regularity of injury and prognosis of this kind of trauma. An animal model of abdominal blast injury complicated with visceral organ exposure was established, which could survive for a long time after injury. Methods: twelve rabbits were randomly divided into two groups, 6 rabbits in each group. Under the condition of general anesthesia, prepare skin marking wound site in advance. The experimental group was treated with self-made celiac protective device, then the 0.125gTNT equivalent explosive ball was applied to the injured site, and the control group was directly injured by the same explosive source without protective treatment. The gross morphology of experimental animals in each group was observed after injury. Pathological sections were observed on the injured tissues of living animals every day. The survival time of dead animals was recorded and autopsies were performed. Results: the abdominal wall of both groups showed open blast injury. The wound area of the experimental group was 3.8 鹵0.56 cm 2, while that of the control group was 3.93 鹵0.49cm2.P0.05. There was no significant difference between the two groups. The survival time of experimental group was 142 鹵87.78 hours. The average survival time of the experimental animals in the control group was 3.77 鹵2.25h. P 0.05. There was significant difference in survival time between the two groups. The experimental group was significantly longer than the control group. Postmortem and pathological observation showed that the causes of early death in the control group were abdominal hemorrhage and visceral injury, while visceral fiber adhesion occurred in the experimental group, but no obvious visceral trauma was found in the experimental group. Pathological sections showed that there were some differences in the explosive trauma of the abdominal wall, showing the pathological changes of "external light and internal weight", and progressive development. The change of muscle tissue was the most typical. Conclusion: the mechanism of abdominal wall explosion injury complicated with visceral organ exposure was simulated in this study. The animal model of simple abdominal wall explosion injury with long survival time after injury was established by effective protection.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R-332

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