【摘要】：持留菌或持留細胞(Persister)是指微生物在受到有效抗菌藥物作用時,絕大部分微生物很快死亡,同時殘留了一小部分代謝活動低下、具有同基因型多藥物耐受(Multidrug Tolerance,MDT)特性的微生物亞群(sub-population)。持留菌與耐藥菌(resistant mutant)是不同的概念,持留菌是表型變異株(Phenotypic Heterogeneity),其基因序列沒有發(fā)生突變,最小抑菌濃度(Minimal Inhibitory Concentration,MIC)不會增大,但持留菌的存在卻是慢性感染性疾病反復發(fā)作、遷延不愈的主要原因。國外已經(jīng)開展了大量實驗來研究持留菌產(chǎn)生及其抗生素耐藥的機制,本文將對持留菌的生物學特性、產(chǎn)生機制、耐藥機制和有效的抗菌策略等內(nèi)容進行綜述。
[Abstract]:Retention bacteria or retention cell (Persister) means that when microbes are exposed to effective antimicrobial agents, the majority of microbes die quickly, while a small fraction of metabolic activity remains low, and they have multiple drug tolerance to (Multidrug Tolerance, with the same genotype. MDT, a subgroup of microorganisms (sub-population). The concept of (resistant mutant) is different from that of resistant strains. Retention strain is a phenotypic variant strain (Phenotypic Heterogeneity), whose gene sequence does not mutate and minimum inhibitory concentration (Minimal Inhibitory Concentration,MIC) does not increase. However, the presence of residual bacteria is the main cause of repeated attacks of chronic infectious diseases. A large number of experiments have been carried out abroad to study the mechanism of antibiotic resistance and its production. In this paper, the biological characteristics, production mechanism, drug resistance mechanism and effective antimicrobial strategies of retained bacteria are reviewed.
【作者單位】： 成都中醫(yī)藥大學醫(yī)學技術(shù)學院;
【基金】：四川省科技廳應用基礎(chǔ)項目(課題編號:2015JY0159)
【分類號】：R378

【相似文獻】

相關(guān)期刊論文 前2條

1 姜北;黎庶;胡曉梅;;持留菌研究方法的新進展[J];醫(yī)學研究生學報;2014年06期

2 吳艷霞;熊靜遠;田蓮田;裴曉方;Yunrong Chai;;微生物持留菌與醫(yī)療衛(wèi)生[J];現(xiàn)代預防醫(yī)學;2014年05期

相關(guān)博士學位論文 前1條

1 韓儉;金黃色葡萄球菌持留菌和L-型形成機制研究[D];蘭州大學;2014年

相關(guān)碩士學位論文 前2條

1 馬亞男;鮑曼不動桿菌耐藥持留菌的形成機制研究[D];安徽大學;2015年

2 姜北;金黃色葡萄球菌轉(zhuǎn)座子突變文庫構(gòu)建與持留性突變株研究[D];第三軍醫(yī)大學;2014年

，

本文編號：2316195