天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

不同構(gòu)建方法對腎陽虛大鼠模型的影響

發(fā)布時間:2018-10-22 16:36
【摘要】:目的:探討簡便有效的腎陽虛建模方法及對大鼠的影響,為方劑藥效學(xué)及機制研究奠定基礎(chǔ)。方法:用腺嘌呤皮下注射和氫化可的松肌肉注射構(gòu)建腎陽虛大鼠模型,觀察大鼠表現(xiàn)及腎臟睪丸病理變化,測定其臟器指數(shù)、自主活動度、游泳時間、血清尿素(SU)、血清肌酐(Cr)、SOD和MDA活力。結(jié)果:與空白組相比,兩種建模方法均使大鼠自主活動度和游泳時間降低(P0.05),腎臟指數(shù)和睪丸指數(shù)增高(P0.05);腺嘌呤組大鼠的Cr水平、SOD活力和MDA活力均升高(P0.05);氫化可的松組大鼠的Cr水平和SOD活力降低(P0.05)、MDA活力升高(P0.05);病理變化上,兩種建模方法均出現(xiàn)炎性細胞浸潤腎間質(zhì)、睪丸生精小管略萎縮,排列疏松,各級生精細胞排列松散等現(xiàn)象。結(jié)論:腺嘌呤與氫化可的松構(gòu)建腎陽虛模型在虛證表現(xiàn)和腎臟睪丸病變上相似,但腺嘌呤可能是通過損害腎濾過水平、睪丸生理功能等引起Cr、SOD和MDA活力升高,氫化可的松則可能是通過耗散機體能量,減弱機體抵抗能力,影響Cr生成、降低SOD活力和增高MDA活力,具體原因有待進一步探究。
[Abstract]:Objective: to explore a simple and effective modeling method of kidney-yang deficiency and its effect on rats, so as to lay a foundation for the pharmacodynamics and mechanism of prescription. Methods: the rat model of kidney yang deficiency was established by subcutaneous injection of adenine and intramuscular injection of hydrocortisone. Serum urea (SU), serum creatinine (Cr), SOD and MDA activity. Results: compared with the blank group, Both modeling methods decreased autonomous activity and swimming time of rats (P0.05), increased renal index and testicular index (P0.05), increased Cr level, SOD activity and MDA activity of rats in adenine group (P0.05); Cr level and SOD level in hydrocortisone group rats. The activity of), MDA was decreased (P0.05), the activity of), MDA was increased (P0.05), and the pathological changes were observed. The inflammatory cells infiltrated the renal interstitial cells, the testicular seminiferous tubules shrank slightly, the arrangement of spermatogenic cells was loose, and so on. Conclusion: the kidney yang deficiency model constructed by adenine and hydrocortisone is similar in deficiency syndrome and renal testicular lesion, but adenine may cause the increase of Cr,SOD and MDA activity by damaging renal filtration level and testicular physiological function. Hydrocortisone may dissipate body energy, weaken body resistance, affect Cr production, decrease SOD activity and increase MDA activity. The specific reasons need to be further explored.
【作者單位】: 廣州中醫(yī)藥大學(xué);廣州中醫(yī)藥大學(xué)附屬寶安中醫(yī)院;
【基金】:國家自然科學(xué)基金資助項目(81102714) 國家級大學(xué)生創(chuàng)新訓(xùn)練項目(201410572026) 廣東省大學(xué)生創(chuàng)新訓(xùn)練項目(201410572077)
【分類號】:R285.5;R-332

【相似文獻】

相關(guān)期刊論文 前1條

1 張翥;馬繼偉;;溢尿靈對腎陽虛大鼠模型免疫器官的影響[J];天津中醫(yī)藥;2007年01期

,

本文編號:2287709

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/xiyixuelunwen/2287709.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶7a24f***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
偷拍偷窥女厕一区二区视频| 美日韩一区二区精品系列| 九九久久精品久久久精品| 国产中文字幕一二三区| 欧美日韩在线视频一区| 国产精品亚洲综合色区韩国| 日本精品免费在线观看| 黄色片一区二区在线观看| 麻豆亚州无矿码专区视频| 成人欧美一区二区三区视频| 亚洲精品国产精品日韩| 一区中文字幕人妻少妇 | 亚洲另类欧美综合日韩精品| 亚洲中文字幕亲近伦片| 亚洲国产精品肉丝袜久久| 久久三级国外久久久三级| 国产日韩精品欧美综合区| 人妻人妻人人妻人人澡| 日韩一区二区三区有码| 国产日韩欧美综合视频| 日韩黄色一级片免费收看| 日本人妻精品有码字幕| 久久精品亚洲欧美日韩| 欧美日韩国产成人高潮| 日韩精品一区二区不卡| 在线免费视频你懂的观看| 东北女人的逼操的舒服吗| 国产美女网红精品演绎| 后入美臀少妇一区二区| 日韩欧美中文字幕av| 成人午夜免费观看视频| 亚洲a码一区二区三区| 美女被后入视频在线观看| 亚洲欧美日本国产有色| 国产欧美日韩精品成人专区| 有坂深雪中文字幕亚洲中文 | 国产精品亚洲二区三区| 欧美不卡高清一区二区三区| 国产又粗又爽又猛又黄的| 欧美一区日韩一区日韩一区| 91精品国产综合久久精品|