發(fā)布時(shí)間：2018-10-22 15:48

【摘要】：正缺氧誘導(dǎo)因子1(hypoxia induced factor 1,Hif-1)是介導(dǎo)細(xì)胞對(duì)缺氧微環(huán)境進(jìn)行適應(yīng)性反應(yīng)的關(guān)鍵轉(zhuǎn)錄調(diào)控因子,在血管新生、能量代謝、細(xì)胞增殖、免疫應(yīng)答、組織纖維化和修復(fù)等方面起重要作用。Hif-1是1992年Semenza等~([1])在低氧處理肝癌細(xì)胞株Hep3B時(shí)發(fā)現(xiàn)的,第一個(gè)被證實(shí)的靶基因是人促紅細(xì)胞生成素(human erythropoietin,EPO),在細(xì)胞適應(yīng)低氧環(huán)境和腫瘤發(fā)展的過(guò)程中,Hif-1扮
[Abstract]:Positive hypoxia inducible factor 1 (hypoxia induced factor 1 (Hif-1) is a key transcriptional regulator for the adaptive response of cells to anoxic microenvironment. It plays an important role in angiogenesis, energy metabolism, cell proliferation and immune response. Tissue fibrosis and repair play an important role. Hif-1 was discovered by Semenza et al. (1) in 1992 when Hep3B cells were treated with hypoxia. The first confirmed target gene is human erythropoietin (human erythropoietin,EPO), which Hif-1 plays during cell adaptation to hypoxia and tumor development.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院病原生物學(xué)系;華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院康復(fù)科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No.81470855) 華中科技大學(xué)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃資助項(xiàng)目(No.2016-0118540283) 湖北省自然科學(xué)基金青年項(xiàng)目(No.2015CFB376)
【分類(lèi)號(hào)】：R364.4
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本文編號(hào)：2287596