本文選題：丹參酮 + 左氧氟沙星�。� 參考：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2017年05期

【摘要】：目的:探討丹參酮對左氧氟沙星在盆腔炎模型大鼠子宮組織中分布的影響。方法:選取96只盆腔炎模型大鼠,隨機(jī)分為實(shí)驗(yàn)組和對照組,每組48只,實(shí)驗(yàn)組肌注丹參酮(8 mg/kg),對照組肌注相同體積生理鹽水;1 h后,2組動物均按80 mg/kg灌服左氧氟沙星(Levofloxacin,LVFX),于灌服LVFX后的0.25、0.5、1.0、1.5、2.0、4.0、8.0、12.0 h不同時(shí)間點(diǎn),2組動物分別處死大鼠6只,采集血漿和子宮組織。高效液相色譜法法測定血漿和子宮組織中LVFX濃度,DAS2計(jì)算藥動學(xué)參數(shù)。結(jié)果:實(shí)驗(yàn)組和對照組血漿與子宮組織血藥濃度-時(shí)時(shí)間曲線均為二室模型,主要藥動學(xué)參數(shù)列舉如下:血漿中峰濃度Cmax分別為(14.341±1.551)μg/m L和(12.780±1.062)μg/m L,子宮組織中C_(max)分別為(13.910±1.704)μg/m L和(11.671±1.134)μg/m L(P0.05);血漿中達(dá)峰時(shí)間tmax分別為(1.329±0.269)h和(1.249±0.264)h,子宮組織中t_(max)分別為(1.419±0.380)h,(1.280±0.270)h;血漿中藥物的半衰期t1/2β分別為(6.284±1.132)h和(5.442±2.590)h,子宮組織中t1/2β分別為(7.920±2.802)h和(3.894±1.595)h(P0.05);血漿中曲線下面積AUC0→t分別為(62.667±4.516)μg·h/m L和(55.693±3.138)μg·h/m L(P0.05),子宮組織中AUC0→t分別為(55.518±11.709)μg·h/m L和(40.374±2.892)μg·h/m L(P0.05)。結(jié)論:丹參酮能明顯增加盆腔炎模型大鼠子宮組織中左氧氟沙星的分布。
[Abstract]:Aim: to investigate the effect of tanshinone on the distribution of levofloxacin in uterus of rats with pelvic inflammatory disease. Methods: 96 rats with pelvic inflammatory disease were randomly divided into experimental group and control group with 48 rats in each group. The experimental group was injected with tanshinone (8 mg/kg), the control group was injected with the same volume of normal saline for 1 h and the two groups were given Levofloxacin (LVFX) at 80 mg/kg. Plasma and uterine tissue were collected. Determination of LVFX concentration in plasma and uterine tissue by high performance liquid chromatography (HPLC) DAS2 was used to calculate the pharmacokinetic parameters. Results: the plasma concentration-time curves of plasma and uterine tissue in the experimental group and the control group were all two-compartment models. The main pharmacokinetic parameters were listed as follows: plasma peak concentration C max was (14.341 鹵1.551) 渭 g / mL and (12.780 鹵1.062) 渭 g / mL, C _ (max) in uterine tissue was (13.910 鹵1.704) 渭 g / mL and (11.671 鹵1.134) 渭 g / m / L (P0.05), plasma peak time (tmax) was (1.329 鹵0.269) h and (1.249 鹵0.264) h, t _ (max) in uterine tissue was (1.419 鹵0.380) h, (1.280 鹵0.270) h, in plasma drug concentration was (1.329 鹵0.269) h and (1.249 鹵0.264) h, respectively. 鐨勫崐琛版湡t1/2尾鍒嗗埆涓，

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