發(fā)布時(shí)間：2018-06-25 06:00

  本文選題：法醫(yī)學(xué) + 常染色體　； 參考：《鄭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年03期

【摘要】：目的:對(duì)新疆哈薩克族進(jìn)行群體遺傳學(xué)數(shù)據(jù)調(diào)查,并將其結(jié)果用于40個(gè)中國(guó)人群間的遺傳距離和遺傳關(guān)系分析。方法:檢測(cè)新疆哈薩克族人群血樣中15個(gè)常染色體STR位點(diǎn);收集公開發(fā)表的中國(guó)多省份、多民族、多人群相應(yīng)的15個(gè)常染色體STR頻率數(shù)據(jù),以Phylip 3.69及Arlequin 3.5統(tǒng)計(jì)軟件包計(jì)算40個(gè)族群之間的Nei's遺傳距離(Rst值),并以Neighbor-Joining法構(gòu)建40個(gè)族群之間的系統(tǒng)發(fā)生樹。結(jié)果:在新疆哈薩克族中,除TPOX以外,其他14個(gè)STR的He、PIC均在0.7以上。全部40個(gè)人群之間的Rst均值為0.055 1,其中18個(gè)漢族人群之間的Rst均值為0.044 9,22個(gè)少數(shù)民族間的Rst均值為0.057 6。從系統(tǒng)發(fā)生樹中發(fā)現(xiàn)漢族分支多且愈來(lái)愈多樣化,我國(guó)境內(nèi)一些距離稍遠(yuǎn)的少數(shù)民族之間有一定的聚合。結(jié)論:法醫(yī)學(xué)常用的15個(gè)常染色體STR在新疆哈薩克族中具有高度遺傳多態(tài)性。
[Abstract]:Objective: to investigate the population genetic data of Kazak nationality in Xinjiang and apply the results to the analysis of genetic distance and genetic relationship among 40 Chinese populations. Methods: 15 autosomal STR loci in Xinjiang Kazak blood samples were detected and 15 autosomal STR frequency data were collected and published in various provinces, nationalities and populations in China. The Neis genetic distance (RST) between 40 populations was calculated by Arlequin 3.69 and Arlequin 3.5.The phylogenetic tree of 40 populations was constructed by Neighbor-Joining method. Results: except for TPOX, all the 14 STR's Hejiao PIC were above 0.7 in Xinjiang Kazak nationality. The mean value of rst among all 40 groups was 0.055, among which the mean value of rst among 18 Han people was 0.044 9, and the mean value of rst among 22 ethnic minorities was 0.057 6. From the phylogenetic tree, it is found that the branches of Han nationality are more and more diversified. Conclusion: 15 autosomal STRs commonly used in forensic medicine are highly polymorphic in Xinjiang Kazak nationality.
【作者單位】： 安徽省阜陽(yáng)市公安局刑科所;鄭州大學(xué)基礎(chǔ)醫(yī)學(xué)院法醫(yī)學(xué)教研室;成都中醫(yī)藥大學(xué)第二附屬醫(yī)院生殖醫(yī)學(xué)中心;烏魯木齊市婦幼保健院檢驗(yàn)科;山西運(yùn)城護(hù)理職業(yè)學(xué)院;鄭州大學(xué)法學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目31071100 河南省教育廳高等學(xué)校重點(diǎn)科研項(xiàng)目15A180021
【分類號(hào)】：R394

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