本文選題：SD大鼠 + 皮膚脫毛��； 參考：《中國比較醫(yī)學(xué)雜志》2017年09期

【摘要】：目的對SD大鼠皮膚進(jìn)行脫毛參數(shù)研究,為建立皮膚光老化動(dòng)物模型提供基本實(shí)驗(yàn)條件。方法以毛發(fā)殘存量和皮損面積為評價(jià)指標(biāo),分別考察Na_2S作用濃度及時(shí)間對脫毛效果的影響,在此基礎(chǔ)上進(jìn)一步通過D-最優(yōu)設(shè)計(jì)優(yōu)化Na_2S脫毛參數(shù)。結(jié)果 Na_2S濃度是影響脫毛能力的關(guān)鍵因素,5%以下幾乎無脫毛效果,7%以上則開始出現(xiàn)皮損并逐步加重,6%為脫毛基礎(chǔ)濃度;在6%Na_2S濃度下作用5 min開始脫毛,10 min時(shí)皮膚表面較光滑,15 min時(shí)非常光滑,15 min之后皮損顯現(xiàn),20 min時(shí)皮損加重,25 min時(shí)肉眼可見皮膚灼燒樣外觀,D-最優(yōu)設(shè)計(jì)表明7%Na_2S作用10 min效果最好,未見皮損且無殘余毛發(fā)。結(jié)論基于D-最優(yōu)設(shè)計(jì)的SD大鼠皮膚化學(xué)脫毛可實(shí)現(xiàn)高效脫毛。
[Abstract]:Objective to study the depilation parameters of SD rat skin and provide basic experimental conditions for the establishment of animal model of skin photoaging. Methods the effects of Na2S concentration and time on the depilation effect were investigated by using the residual amount of hair and the area of skin lesion as the evaluation indexes. On the basis of this, the parameters of hair removal of NaSs were optimized by D- optimal design. Results the concentration of Na2S was the key factor affecting the ability of depilation. Under 5% there was almost no effect of depilation more than 7% of which appeared skin damage and gradually aggravated 6% of the base concentration of depilation. The skin surface was smoother at the concentration of 6% Na2S for 5 min, and the skin surface was very smooth at 15 min. After the skin lesion appeared, the skin lesion increased at 20 min and the skin burned out at 25 min. The best design showed that 7Na2S had the best effect on 10 min. No skin lesions and no residual hair. Conclusion Chemical depilation of SD rat skin based on D-optimal design can achieve high-efficiency depilation.
【作者單位】： 廣東海洋大學(xué)食品科技學(xué)院廣東省水產(chǎn)品加工與安全重點(diǎn)實(shí)驗(yàn)室廣東省海洋食品工程技術(shù)研究中心水產(chǎn)品深加工廣東普通高等學(xué)校重點(diǎn)實(shí)驗(yàn)室;華南理工大學(xué)輕工與食品學(xué)院;無限極(中國)有限公司技術(shù)中心;西藏大學(xué)農(nóng)牧學(xué)院動(dòng)物科學(xué)學(xué)院;
【基金】：中國博士后科學(xué)基金項(xiàng)目(編號:2014M552203) 中央高�；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金資助(編號:20152M062) 國家級大學(xué)生創(chuàng)新課題(編號:20161056601)
【分類號】：R-332
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本文編號：2040031