本文選題：SD大鼠 + 皮膚脫毛�。� 參考：《中國比較醫(yī)學雜志》2017年09期

【摘要】：目的對SD大鼠皮膚進行脫毛參數(shù)研究,為建立皮膚光老化動物模型提供基本實驗條件。方法以毛發(fā)殘存量和皮損面積為評價指標,分別考察Na_2S作用濃度及時間對脫毛效果的影響,在此基礎上進一步通過D-最優(yōu)設計優(yōu)化Na_2S脫毛參數(shù)。結果 Na_2S濃度是影響脫毛能力的關鍵因素,5%以下幾乎無脫毛效果,7%以上則開始出現(xiàn)皮損并逐步加重,6%為脫毛基礎濃度;在6%Na_2S濃度下作用5 min開始脫毛,10 min時皮膚表面較光滑,15 min時非常光滑,15 min之后皮損顯現(xiàn),20 min時皮損加重,25 min時肉眼可見皮膚灼燒樣外觀,D-最優(yōu)設計表明7%Na_2S作用10 min效果最好,未見皮損且無殘余毛發(fā)。結論基于D-最優(yōu)設計的SD大鼠皮膚化學脫毛可實現(xiàn)高效脫毛。
[Abstract]:Objective to study the depilation parameters of SD rat skin and provide basic experimental conditions for the establishment of animal model of skin photoaging. Methods the effects of Na2S concentration and time on the depilation effect were investigated by using the residual amount of hair and the area of skin lesion as the evaluation indexes. On the basis of this, the parameters of hair removal of NaSs were optimized by D- optimal design. Results the concentration of Na2S was the key factor affecting the ability of depilation. Under 5% there was almost no effect of depilation more than 7% of which appeared skin damage and gradually aggravated 6% of the base concentration of depilation. The skin surface was smoother at the concentration of 6% Na2S for 5 min, and the skin surface was very smooth at 15 min. After the skin lesion appeared, the skin lesion increased at 20 min and the skin burned out at 25 min. The best design showed that 7Na2S had the best effect on 10 min. No skin lesions and no residual hair. Conclusion Chemical depilation of SD rat skin based on D-optimal design can achieve high-efficiency depilation.
【作者單位】： 廣東海洋大學食品科技學院廣東省水產(chǎn)品加工與安全重點實驗室廣東省海洋食品工程技術研究中心水產(chǎn)品深加工廣東普通高等學校重點實驗室;華南理工大學輕工與食品學院;無限極(中國)有限公司技術中心;西藏大學農(nóng)牧學院動物科學學院;
【基金】：中國博士后科學基金項目(編號:2014M552203) 中央高�；究蒲袠I(yè)務費專項資金資助(編號:20152M062) 國家級大學生創(chuàng)新課題(編號:20161056601)
【分類號】：R-332
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本文編號：2040031