發(fā)布時間：2018-02-24 10:47

  本文關(guān)鍵詞： 發(fā)熱伴出疹癥候群 病毒性病原譜 流行病學(xué)　出處：《病毒學(xué)報》2017年02期 　論文類型：期刊論文

【摘要】：本研究通過對中國山西省2009~2015年哨點醫(yī)院所采集的發(fā)熱伴出疹癥候群(Rash and fever syndrome,RFS)監(jiān)測病例中六種病毒性病原體(麻疹病毒,風(fēng)疹病毒,腸道病毒,水痘-帶狀皰疹病毒,人類小DNA病毒B19和登革病毒)進(jìn)行描述性流行病學(xué)研究,闡明RFS在人群和時間的分布特點,揭示山西省2009~2015年RFS六種病毒病原譜構(gòu)成及其流行規(guī)律,為山西省進(jìn)一步開展RFS的預(yù)防和控制工作提供科學(xué)依據(jù)。在2009年1月1日至2015年12月31日期間,山西省共檢測RFS監(jiān)測病例846例,檢出RFS病毒性病原陽性病例504例,陽性率為59.57%。其中麻疹病毒陽性192例(38.10%),腸道病毒陽性93例(18.45%),風(fēng)疹病毒陽性87例(17.26%),水痘-帶狀皰疹病毒陽性83例(16.47%),人類小DNA病毒B19陽性48例(9.52%),登革病毒陽性1例(0.20%)。RFS陽性病例主要集中在15歲以下的兒童和學(xué)生,不同性別之間病原檢出率無統(tǒng)計學(xué)差異,但不同年齡組的病原譜構(gòu)成略有差異。RFS發(fā)病呈現(xiàn)出明顯的季節(jié)性,3~8月為其發(fā)病高峰。監(jiān)測數(shù)據(jù)提示我國應(yīng)加強(qiáng)RFS系統(tǒng)性和連續(xù)性監(jiān)測,將15歲以下的兒童和青少年作為重點監(jiān)測人群,不同省份和地市可根據(jù)實際發(fā)病情況制定出具體的、有針對性的監(jiān)測方案,以闡明本省或本地區(qū)RFS病毒病原的構(gòu)成及其流行規(guī)律和疾病負(fù)擔(dān)。
[Abstract]:In this study, six viral pathogens (measles virus, rubella virus, enterovirus, varicella zoster virus) were collected from Sentinel Hospital of Shanxi Province from 2009 to 2015. A descriptive epidemiological study of human small DNA virus B19 and dengue virus was carried out to elucidate the distribution characteristics of RFS in population and time, and to reveal the composition and epidemic pattern of six kinds of RFS viruses from 2009 to 2015 in Shanxi Province. From January 1st 2009 to December 31st 2015, a total of 846 RFS surveillance cases were detected in Shanxi Province, and 504 positive cases of RFS virus pathogen were detected in Shanxi Province. The positive rate was 59.57.The positive rate of measles virus was 38.1010 in 192 cases, intestinal virus was 18.45, rubella virus was positive in 87 cases, varicella-zoster virus was positive in 83 cases, human small DNA virus B19 positive in 48 cases, dengue virus positive in 1 case. Sexual cases are concentrated in children and students under the age of 15, There was no statistical difference in the detection rate of pathogens among different genders, but there was a slight difference in the composition of pathogeny spectrum among different age groups. The incidence of RFS showed obvious seasonal peak from 3 to August. The monitoring data suggested that the systematic and continuous monitoring of RFS should be strengthened in China. With children and adolescents under the age of 15 as the focus groups, specific and targeted surveillance programmes can be developed in different provinces and municipalities according to the actual incidence of the disease. In order to elucidate the constitution, epidemic regularity and disease burden of RFS virus in our province or region.
【作者單位】： 中國疾病預(yù)防控制中心病毒病預(yù)防控制所衛(wèi)生部醫(yī)學(xué)病毒與病毒病重點實驗室;山西省疾病預(yù)防控制中心;
【基金】：“十一五”和“十二五”國家科技重大專項(項目號:2009ZX10004201,2009ZX10004202,2012ZX10004201,2013ZX10004202),題目:“艾滋病和病毒性肝炎等重大傳染病防治”科技重大專項傳染病監(jiān)測技術(shù)平臺項目
【分類號】：R373

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