本文關(guān)鍵詞：小型豬慢性心肌缺血模型的建立與無(wú)創(chuàng)遙測(cè)技術(shù)的應(yīng)用　出處：《中國(guó)比較醫(yī)學(xué)雜志》2017年05期 　論文類型：期刊論文

  更多相關(guān)文章： 小型豬 慢性心肌缺血 無(wú)創(chuàng)遙測(cè)技術(shù) 動(dòng)脈粥樣硬化 心率變異性 適應(yīng)恢復(fù)期

【摘要】：為建立小型豬慢性心肌缺血模型和應(yīng)用無(wú)創(chuàng)遙測(cè)技術(shù)的評(píng)價(jià)方法,本研究采用維生素D3和異丙腎上腺素復(fù)合高脂飲食的方法建立了小型豬慢性心肌缺血模型;并利用無(wú)創(chuàng)遙測(cè)技術(shù)對(duì)小型豬慢性心肌缺血模型的癥狀進(jìn)行檢測(cè)與評(píng)價(jià),同時(shí)對(duì)五指山小型豬、巴馬小型豬和西藏小型豬的運(yùn)輸應(yīng)激和高脂誘導(dǎo)發(fā)生動(dòng)脈粥樣硬化(AS)的危險(xiǎn)因素進(jìn)行評(píng)估。建立了巴馬小型豬慢性心肌缺血模型與評(píng)價(jià)技術(shù)規(guī)范,明確了無(wú)創(chuàng)遙測(cè)技術(shù)可用于心肌缺血模型的癥狀檢測(cè)和評(píng)價(jià),界定了小型豬運(yùn)輸應(yīng)激后需4周以上的適應(yīng)恢復(fù)期。并發(fā)現(xiàn)了高脂環(huán)境下五指山小型豬、巴馬小型豬和西藏小型豬發(fā)生高血脂、高血壓、高胰島素血癥等AS危險(xiǎn)因素的不同特征,這為小型豬在心血管疾病研究中的選擇和應(yīng)用提供參考。
[Abstract]:As the evaluation method to establish the swine model of chronic myocardial ischemia and application of non-invasive telemetry technology and methods used in the study of vitamin D3 and isoproterenol combined high fat diet to establish chronic myocardial ischemia model in pigs; and the use of noninvasive model of chronic myocardial ischemia telemetry on miniature pigs symptoms were detected and evaluated at the same time. The Five Fingers Group miniature pig, Bama miniature pig and Tibet pig transport stress and high fat induced atherosclerosis (AS) risk factor assessment. A chronic myocardial ischemia model and evaluation specification for Bama miniature pig has been established. It is clear that the non-invasive telemetry technology can be used for symptom detection and evaluation of myocardial ischemia model, and the adaptive recovery period for minipigs after transportation stress is defined for more than 4 weeks. We also found different characteristics of AS risk factors such as hyperlipidemia, hypertension and hyperinsulinemia in Five Fingers Group miniature pigs, Bama miniature pigs and Tibet miniature pigs under high fat environment. This provides a reference for selection and application of miniature pigs in cardiovascular disease research.
【作者單位】： 浙江中醫(yī)藥大學(xué)動(dòng)物實(shí)驗(yàn)研究中心/比較醫(yī)學(xué)研究所;
【基金】：省部共建科研基金(WKJ2009-2-032) 浙江中醫(yī)藥大學(xué)比較醫(yī)學(xué)創(chuàng)新團(tuán)隊(duì)(XTD201301)
【分類號(hào)】：R-332;R542.2
【正文快照】： cmli991@aliyun.com1研究背景心血管疾病是嚴(yán)重危害人民健康的常見(jiàn)病、多發(fā)病之一。冠狀動(dòng)脈性心臟病又稱缺血性心臟病,簡(jiǎn)稱冠心病,是一種嚴(yán)重的心血管系統(tǒng)疾病,已成為死亡的主要原因之一。隨著我國(guó)的改革開(kāi)放,經(jīng)濟(jì)迅猛發(fā)展,人們的生活水平、方式、節(jié)奏、社會(huì)和心理壓力都發(fā)生，

本文編號(hào)：1341316