本文選題：非酒精性脂肪肝　切入點(diǎn)：γ-谷氨酰轉(zhuǎn)肽酶　出處：《青海大學(xué)》2017年碩士論文

【摘要】：目的:通過檢測(cè)青海地區(qū)非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)患者血清γ-谷氨酰轉(zhuǎn)移酶(γ-GT)、膽堿酯酶(CHE)和胰島素抵抗指數(shù)(IR),探討其對(duì)診斷NAFLD的預(yù)測(cè)價(jià)值。方法:1.收集我院消化內(nèi)科于2015年11月到2016年11月診斷為非酒精性脂肪肝的患者73例,以同期在體檢中心體檢的正常健康者77例作為對(duì)照。2.非酒精性脂肪肝通過腹部CT檢查明確,兩組均測(cè)定血清葡萄糖、血脂和肝功能及血清胰島素水平。通過穩(wěn)態(tài)模型評(píng)價(jià)(HOMA)計(jì)算HOMA-IR(IR)、HOMA-IS和HOMAβ。結(jié)果:1.NAFLD組BMI、ALT、TG、FBG、γ-GT和HOMA-IR水平高于正常對(duì)照組,有統(tǒng)計(jì)學(xué)差異(P0.05),HOMA-IS水平低于正常對(duì)照組,有統(tǒng)計(jì)學(xué)差異(P0.05),CHE、HOMAβ比較無統(tǒng)計(jì)學(xué)差異(P0.05)。2.γ-GT(OR=1.235,P0.05)和HOMA-IR(OR=17.247,P0.05)都是NAFLD的獨(dú)立危險(xiǎn)因素。3.HOMA-IR預(yù)測(cè)NAFLD的最佳切點(diǎn)值為1.76,敏感度為78.1%,特異度為64.9%;同理γ-GT最佳切點(diǎn)值為24.7U/L,敏感度為56.2%,特異度為83.1%。結(jié)論:1.青海地區(qū)非酒精性脂肪肝患者血清中γ-GT、IR、ALT、TG、FBG升高;HOMA-IS水平降低;而CHE、HOMAβ水平無差異;2.血清γ-GT和IR可作為預(yù)測(cè)NAFLD發(fā)生的獨(dú)立危險(xiǎn)因素,聯(lián)合檢測(cè)對(duì)NAFLD診斷有早期的預(yù)測(cè)價(jià)值。
[Abstract]:Objective: to investigate the predictive value of serum 緯 -glutamyl transferase (緯 -GT) and insulin resistance index (IRI) in patients with nonalcoholic fatty liver disease (NAF LDD) in Qinghai area.Method 1: 1.From November 2015 to November 2016, 73 cases of non-alcoholic fatty liver were diagnosed in the Department of Digestive Medicine of our hospital, and 77 cases of normal health checked in the same period were used as control.Non-alcoholic fatty liver was determined by abdominal CT. Serum glucose, blood lipid, liver function and serum insulin were measured in both groups.HOMA-IS and HOMA 尾 were calculated by steady-state model evaluation.Results 1. The levels of HOMA-IR, 緯 -GT and BMIT in NAFLD group were higher than those in normal control group, and the levels of HOMA-IS in NAFLD group were lower than those in normal control group.鏈夌粺璁″宸紓(P0.05),CHE,HOMA尾姣旇緝鏃犵粺璁″宸紓(P0.05).2.緯-GT(OR=1.235,P0.05)鍜孒OMA-IR(OR=17.247,P0.05)閮芥槸NAFLD鐨勭嫭绔嬪嵄闄╁洜绱，

本文編號(hào)：1702052