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  本文選題：分裂型人格障礙 + 功能核磁共振�。� 參考：《大連醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的 通過隨機(jī)對照研究，探討年齡為19-21的青春后期分裂型人格障礙者和健康對照組之間大腦白質(zhì)的差異。為了發(fā)現(xiàn)分裂癥系譜早期階段可能存在的白質(zhì)病變部位，進(jìn)行概率追蹤比較兩組被試右側(cè)內(nèi)嗅皮層與額葉間神經(jīng)纖維束連接差異。 對象 某大學(xué)3500名一年級男生在知情同意的情況下，接受了MMPI篩查，篩出精神病質(zhì)（Sc）分大于等于70分的75名個體，他們進(jìn)一步的接受了分裂型人格障礙調(diào)查問卷（SPQ），同時接受了DSM-IV診斷，最終50名男生被作為研究對象（分裂型人格障礙組），從中隨機(jī)抽取18名作為大腦白質(zhì)纖維研究對象；同時隨機(jī)抽取MMPI人格正常健康的個體18名作為對照組。 方法 36名被試在知情同意情況下，接受了德國GE3.0特斯拉的核磁共振掃描儀的掃描，被試的DTI圖像被采集，，用配對樣本t檢驗比較了兩組人群腦白質(zhì)的FA值的差異；差異部位的FA值與SPQ分值之間的相關(guān)通過Pearson相關(guān)分析方法完成；兩組間差異部位（內(nèi)嗅皮層）到額葉的白質(zhì)纖維追蹤通過概率分析完成，比較了兩組被試內(nèi)嗅皮層—額葉皮層間連接的概率差異。 結(jié)果 1）與健康對照組相比，分裂型人格障礙的被試（SPD）的FA值在右側(cè)顳葉（內(nèi)嗅皮質(zhì)）白質(zhì)密度傾向高于對照組（P=0.09）；2）有差異趨向區(qū)的FA值與分裂型人格問卷中的陽性因子中偏執(zhí)分呈顯著負(fù)相關(guān)（r=-0.486, P=0.042）；FA值和分裂型人格問卷中陽性總分呈有意義的負(fù)相關(guān)（r=-0.525, p=0.025）；FA值與分裂型人格問卷中的陰性維度中的過度焦慮分呈顯著負(fù)相關(guān)（r=-0.53, p=0.024）。3）患有分裂型人格障礙的被試的MMPI的Sc分與分裂型人格問卷（SPQ）的陽性因子的怪異行為維度分呈顯著正相關(guān)（r=0.481, p=0.043）；Sc分也與陽性因子中的不尋常的感知覺體驗呈顯著正相關(guān)(r=0.517,p=0.028)；Sc分與陽性維度中的偏執(zhí)觀念呈顯著正相關(guān)（r=0.517，p=0.028）；Sc分與SPQ問卷的陽性癥狀總分呈顯著正相關(guān)（r=0.472, p=0.048）；4）分裂型人格障礙被試的右側(cè)內(nèi)嗅皮層到腦額葉的神經(jīng)纖維連接概率高于對照組，差異顯著，p0.05。 結(jié)論 分裂型人格障礙組大腦白質(zhì)纖維密度，在右側(cè)顳葉區(qū)域（內(nèi)嗅皮層）趨向高于對照組；說明SPD組右側(cè)內(nèi)嗅皮質(zhì)的白質(zhì)纖維密度越高，內(nèi)嗅皮層傳到額葉的白質(zhì)纖維束的連接概率也越高，而且右側(cè)內(nèi)嗅-額葉纖維白質(zhì)的增加可能對于陽性癥狀的偏執(zhí)、陰性癥狀的焦慮負(fù)有責(zé)任。
[Abstract]:Objective to investigate the difference of white matter between the 19-21 age group with split personality disorder and the healthy control group in a randomized controlled study. In order to find the possible white matter lesions in the early stage of pedigree of schizophrenia, the difference of nerve fiber bundle connections between the right olfactory cortex and frontal lobe in the two groups was compared by probabilistic tracing. Participants 3500 first-year male students in a certain university were screened with MMPI with informed consent, and 75 individuals with a score of more than 70 (SC) were screened. They further received the split personality disorder questionnaire (SPQ) and DSM-IV diagnosis. Finally, 50 male students were selected as the subjects of the study (split personality disorder group), and 18 subjects were randomly selected from the middle of the study as the white matter fiber study subjects. At the same time, 18 individuals with normal MMPI personality were randomly selected as control group. Methods 36 subjects were scanned by GE 3.0 Tesla nuclear magnetic resonance scanner with informed consent, and the difference of FA values in white matter between the two groups was compared with paired t-test. The correlation between FA value and SPQ score was completed by Pearson correlation analysis, and the white matter fibers from the different sites (endolfactory cortex) to frontal lobe were tracked by probability analysis. The probabilities of the connection between olfactory cortex and frontal cortex were compared between the two groups. Results 1) compared with the healthy control group, the FA value of the subjects with split personality disorder (SPD) was higher than that of the control group in the right temporal lobe (endoolfactory cortex) (P < 0.09). 2) there was a significant negative correlation between FA value of different tendency area and paranoid score of positive factor in split personality questionnaire (r-0.486, P0. 042). There was significant negative correlation between FA value and positive total score in split personality questionnaire (r-0.525, p0. 025). There was a significant negative correlation between FA value and the scores of excessive anxiety in the negative dimension of the split personality questionnaire (r-0.53, p0. 024). 3. The SC score of MMPI of subjects with split personality disorder and the weird behavioral dimension of positive factors of split personality questionnaire (SPQ) were significantly negatively correlated with FA value (r-0.53, p0. 024). There was a significant positive correlation (r = 0.481, p = 0.043). The SC score was also positively correlated with the abnormal perceptual experience in the positive factors (rn 0.517 p0. 028) and the paranoid perception in the positive dimension (r 0. 517 p0. 028) SC score was significantly positively correlated with the total score of positive symptoms in SPQ questionnaire (r0. 472, p0. 048), and there was a significant positive correlation between SC score and the total score of positive symptoms in the SPQ questionnaire (r0. 472, p0. 048). 4) the probability of nerve fiber connection from the right olfactory cortex to the frontal lobe of the patients with split personality disorder was higher than that of the control group, and the difference was significant (p 0.05). Conclusion the density of white matter fibers in the right temporal lobe (entorhinal cortex) in the split personality disorder group was higher than that in the control group, indicating that the density of the white matter fiber in the right olfactory cortex of SPD group was higher than that of the control group. The higher the connection probability of the white matter fiber bundle from the endoolfactory cortex to the frontal lobe, and the increase of the white matter in the right endolfactory and frontal lobe may be responsible for the paranoia of positive symptoms and anxiety of negative symptoms.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：B845

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相關(guān)期刊論文 前2條

1 ;表情[J];報林;2012年05期

2 李惠;陳增堂;唐云翔;李春波;肖澤萍;殷芳;王繼軍;;分裂型人格障礙大學(xué)生的社會認(rèn)知功能[J];中國心理衛(wèi)生雜志;2010年04期

本文編號：2108510