本文選題：社會(huì)隔離　切入點(diǎn)：青春期　出處：《首都師范大學(xué)》2014年碩士論文

【摘要】：社會(huì)環(huán)境是影響青春期動(dòng)物藥物成癮易感性的重要因素之一,社會(huì)環(huán)境的這種影響包括社會(huì)隔離和同伴關(guān)系等因素。有關(guān)研究發(fā)現(xiàn),與藥物成癮有關(guān)的新穎尋求行為也在一定程度受社會(huì)環(huán)境影響,而新穎尋求也影響藥物成癮。本研究主要考察在社會(huì)隔離及群組情境下不同藥物處理同伴對(duì)青春期大鼠嗎啡行為敏感化的影響及其與新穎尋求水平可能存在的關(guān)系。 本實(shí)驗(yàn)選用72只青春期Sprague-Dawley大鼠(3周齡),共分為6個(gè)組：?jiǎn)为?dú)飼養(yǎng)的嗎啡處理組和鹽水處理組、兩只共同飼養(yǎng)的嗎啡處理組、兩只共同飼養(yǎng)的鹽水處理組、兩只不同處理混合飼養(yǎng)組中的嗎啡組以及鹽水組。在8天的適應(yīng)飼養(yǎng)后,按照分組對(duì)動(dòng)物進(jìn)行嗎啡(5mg/kg)或鹽水處理7天,經(jīng)過7天的戒斷期之后進(jìn)行行為敏感化測(cè)試,在戒斷期的最后3天進(jìn)行新穎環(huán)境偏愛測(cè)試。 實(shí)驗(yàn)結(jié)果顯示：群組飼養(yǎng)的大鼠的同伴是否接受藥物處理對(duì)動(dòng)物自身的嗎啡成癮無影響；社會(huì)隔離飼養(yǎng)使嗎啡慢性處理導(dǎo)致的青春期大鼠行為敏感化水平提高；而社會(huì)隔離和同伴藥物狀態(tài)只對(duì)鹽水處理組大鼠的新穎環(huán)境偏愛有影響。社會(huì)隔離對(duì)青春期大鼠的新穎環(huán)境偏愛水平和嗎啡行為敏感化的影響并不是完全一致的。 研究結(jié)果表明社會(huì)環(huán)境中同伴的存在對(duì)環(huán)境線索刺激及藥物刺激引起的嗎啡復(fù)吸具有預(yù)防作用。這種社會(huì)環(huán)境對(duì)藥物成癮的影響與對(duì)新穎尋求的影響可能并不涉及共同的機(jī)制。
[Abstract]:Social environment is one of the important factors that influence the susceptibility of adolescent animals to drug addiction. This influence of social environment includes social isolation and peer relationship. Novel seeking behaviors related to drug addiction are also affected to some extent by the social environment, This study investigated the effects of different drug treatment peers on morphine behavior sensitivity in adolescent rats under social isolation and group situations and the possible relationship between novel seeking level and novel seeking level. Seventy-two pubertal Sprague-Dawley rats were divided into 6 groups: morphine treated group and saline group, morphine treated group and saline treated group. After 8 days of adaptation, animals were treated with morphine (5 mg / kg) or saline for 7 days. After 7 days of withdrawal, behavioral sensitivities were tested. Novel environmental preference tests were performed on the last 3 days of the withdrawal period. The results showed that whether the cohort rats were treated with drugs or not had no effect on the morphine addiction of the animals themselves, and that the social isolation raised the behavioral sensitivity of the adolescent rats induced by chronic morphine treatment. However, social isolation and peer drug status had only effects on the novel environmental preference of saline treated rats, and the effects of social isolation on the level of novel environmental preference of adolescent rats were not consistent with those of morphine behavioral sensitivity. The results show that the presence of peers in the social environment can prevent morphine relapse induced by environmental cues and drug stimuli. The effects of this social environment on drug addiction and novel search may not be significant. Involving common mechanisms.
【學(xué)位授予單位】：首都師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：B845

【共引文獻(xiàn)】

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相關(guān)博士學(xué)位論文 前1條

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本文編號(hào)：1683044