【摘要】：目的近年來,有關(guān)pre-miR-27a基因rs895819位點(diǎn)多態(tài)性與大腸癌易感性關(guān)系的研究日益增多,但結(jié)論并不一致。本研究從循證醫(yī)學(xué)角度,綜合評(píng)價(jià)pre-miR-27a基因rs895819位點(diǎn)多態(tài)性與大腸癌易感性的關(guān)系。方法通過檢索數(shù)據(jù)庫PubMed、Cochrane Library、EMBASE以及中國知網(wǎng)數(shù)據(jù)庫、萬方數(shù)據(jù)庫,收集有關(guān)pre-miR-27a基因rs895819位點(diǎn)多態(tài)性與大腸癌罹患風(fēng)險(xiǎn)關(guān)系的病例-對(duì)照研究。檢索時(shí)間1998-01-01-2015-11-01。依據(jù)文獻(xiàn)納入及排除標(biāo)準(zhǔn)篩選相關(guān)文獻(xiàn),提取基本數(shù)據(jù)信息并進(jìn)行文獻(xiàn)質(zhì)量評(píng)估。采用Stata 12.0軟件行Meta分析,計(jì)算合并OR值和95%CI,并進(jìn)一步行亞組分析和敏感性分析。結(jié)果最終納入6個(gè)病例-對(duì)照研究(包括2 025例大腸癌患者和2 320例非腫瘤對(duì)照者)。Meta分析結(jié)果顯示,pre-miR-27a基因rs895819多態(tài)性與大腸癌罹患風(fēng)險(xiǎn)具有顯著的相關(guān)性,Gvs A:OR=1.18,95%CI=1.08~1.30;GG vs AA/AG:OR=1.52,95%CI=1.26~1.97;GG vs AA:OR=1.53,95%CI=1.26~1.86,P值均0.05。亞組分析結(jié)果發(fā)現(xiàn),亞洲人群也有相似的結(jié)論,Gvs A:OR=1.21,95%CI=1.09~1.35;AG/GGvs AA:OR=1.15,95%CI=1.00~1.32;GG vs AA/AG:OR=1.57,95%CI=1.27~1.93;GG vs AA:OR=1.59,95%CI=1.27~1.98,P值均0.05。結(jié)論 pre-miR-27a基因rs895819多態(tài)性與大腸癌易感性之間具有相關(guān)性,并且GG基因型具有增加罹患大腸癌的風(fēng)險(xiǎn)。
[Abstract]:Aim in recent years, the relationship between rs895819 polymorphism of pre-miR-27a gene and susceptibility to colorectal cancer is increasing, but the conclusions are not consistent. In this study, we evaluated the relationship between rs895819 polymorphism of pre-miR-27a gene and susceptibility to colorectal cancer from the point of view of evidence-based medicine. Methods A case-control study on the relationship between rs895819 polymorphism of pre-miR-27a gene and the risk of colorectal cancer was carried out by searching PubMed,Cochrane Library,EMBASE database, China knowledge website database and Wanfang database. Search time 1998 / 01 / 2015 / 11 / 01. According to the criteria of literature inclusion and exclusion, the relevant documents were screened, the basic data information was extracted and the literature quality was evaluated. The combined OR value and 95% CI were calculated by Meta analysis with Stata 12.0 software, and further subgroup analysis and sensitivity analysis were performed. Results six case-control studies (including 2 025 colorectal cancer patients and 2 320 non-tumor controls) were included. Meta-analysis showed that there was a significant correlation between pre-miR-27a gene rs895819 polymorphism and colorectal cancer risk. Gvs A / OR 1.18, 95% CI 1.08 / 1.30; The GG vs AA/AG:OR=1.52,95%CI=1.26~1.97;GG vs AA:OR=1.53,95%CI=1.26~1.86, P values were 0.05. The results of subgroup analysis showed that there were similar conclusions in Asian population, Gvs A / A OR 1.21, 95% CI 1.09 / 1.35 AG / GGvs AA:OR=1.15,95%CI=1.00~1.32;GG vs AA/AG:OR=1.57,95%CI=1.27~1.93; The GG vs AA:OR=1.59,95%CI=1.27~1.98, P values were 0.05. Conclusion rs895819 polymorphism of pre-miR-27a gene is associated with susceptibility to colorectal cancer, and GG genotype may increase the risk of colorectal cancer.
【作者單位】： 南昌大學(xué)第二附屬醫(yī)院胃腸外科;永豐縣人民醫(yī)院普外一科;
【基金】：南昌大學(xué)研究生創(chuàng)新基金(cx2015168)
【分類號(hào)】：R735.34

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