【摘要】：探討單核細(xì)胞趨化蛋白-1(MCP-1)2518 A/G基因多態(tài)性與癌易感性的關(guān)聯(lián)情況。計算機(jī)檢索相關(guān)數(shù)據(jù)庫,收集自建庫至2016年12月國內(nèi)外已發(fā)表的有關(guān)MCP-1-2518 A/G基因多態(tài)性與腫瘤易感性關(guān)聯(lián)的研究。共納入30項病例對照研究(包括5 602例患癌患者和6 500例健康對照人群)。采用Stata 12.0軟件進(jìn)行統(tǒng)計學(xué)分析。Cochran Q檢驗和I2檢驗對各研究進(jìn)行異質(zhì)性檢驗,計算合并比值比(OR值)及其95%可信區(qū)間(95%CI)以評價關(guān)聯(lián)性,Begg's test和Egger's test評估發(fā)表偏倚,并進(jìn)行Meta回歸、敏感性分析。Meta分析結(jié)果提示MCP-1-2518 A/G多態(tài)性與癌患病風(fēng)險無明顯相關(guān)性。但根據(jù)腫瘤類型的亞組分析發(fā)現(xiàn),MCP-1基因多態(tài)性與肝癌、乳腺癌、卵巢癌和非小細(xì)胞肺癌的發(fā)病風(fēng)險顯著相關(guān)(p0.05)。根據(jù)種族進(jìn)行的亞組分析發(fā)現(xiàn),攜GG基因型的白種人群患癌風(fēng)險增加(GG vs.AG/AA:OR=1.81,95%CI=1.10~2.96),而MCP-1-2518 A/G多態(tài)性與亞洲人群患癌風(fēng)險無相關(guān)性(p0.05)。多態(tài)性與癌易感性的關(guān)聯(lián)在基于對照組來源、研究樣本量和低質(zhì)量研究的亞組分析中顯著,而根據(jù)對照組是否符合HWE遺傳平衡和基因檢測方法的亞組分析,這種關(guān)系不顯著。Meta回歸分析表明,種族差異和納入研究的質(zhì)量可能是各研究間異質(zhì)性存在的主要來源。綜上所述,MCP-1-2518 A/G多態(tài)性可能與癌易感性相關(guān),GG基因型可增加白種人群患癌風(fēng)險,MCP-1基因A2518G位點(diǎn)有望作為癌早期診斷和預(yù)后判定的重要分子標(biāo)志物。
[Abstract]:To investigate the association between 2518 A / G polymorphism of monocyte chemoattractant protein-1 (MCP-1) and cancer susceptibility. The related databases were searched by computer, and the published studies on the association of MCP-1-2518 A / R G gene polymorphism with tumor susceptibility were collected from the self-built database up to December 2016 at home and abroad. A total of 30 case-control studies were conducted (including 5 602 cancer patients and 6 500 healthy controls). Stata 12.0 software was used for statistical analysis,. Cochran Q test and I2 test were used to test the heterogeneity of each study. The combined ratio (OR) and its 95% confidence interval (95%CI) were calculated to evaluate the correlation. Begg's test and Egger's test were used to evaluate publication bias, Meta regression and sensitivity analysis. The results of Meta analysis showed that there was no significant correlation between MCP-1-2518 A / G polymorphism and cancer risk. However, according to the subgroup analysis of tumor types, MCP-1 gene polymorphism was significantly associated with the risk of liver cancer, breast cancer, ovarian cancer and non-small cell lung cancer (p0.05). Subgroup analysis based on race found that white people with GG genotype had an increased risk of cancer (GG vs.AG/AA:OR=1.81,95%CI=1.10~2.96). There was no correlation between the MCP-1-2518 A / G polymorphism and the risk of cancer in Asian population (p0.05). The association between polymorphism and susceptibility to cancer was significant in subgroup analysis based on control group origin, sample size and low quality studies, and subgroup analysis based on HWE genetic balance and gene detection methods in the control group. The Meta regression analysis showed that racial differences and the quality of the included studies may be the main sources of heterogeneity among the studies. In conclusion, MCP-1-2518 A / G polymorphism may be associated with cancer susceptibility, and GG genotype may increase the risk of cancer in white race population. The A2518G locus of MCP-1 gene may be an important molecular marker for early diagnosis and prognosis of cancer.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院
【基金】：重慶市衛(wèi)生計生委醫(yī)學(xué)科研重點(diǎn)項目(20141001)資助
【分類號】：R730.2

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