【摘要】：目的研究新疆維吾爾族非小細(xì)胞肺癌(NSCLC)表皮生長因子受體(EGFR)基因突變與病理特征的相關(guān)性。方法回顧性分析2003年1月~2014年1月新疆喀什地區(qū)第二人民醫(yī)院診治的新疆維吾爾族NSCLC患者的組織蠟塊43例,病理標(biāo)本均予EGFR基因突變檢測試劑盒檢測,觀察患者EGFR基因突變檢出率、臨床病癥分型與EGFR基因突變的相關(guān)性,基線資料與EGFR基因突變的相關(guān)性。結(jié)果本組患者病理標(biāo)本EGFR基因突變率為11.63%(5/43),第19外顯子缺失改變率[80.00%(4/5)]顯著高于第21外顯子L858R點(diǎn)突變率[20.00%(1/5)](P0.01);臨床病癥分型中腺癌EGFR基因突變檢出率[19.05%(4/21)]較鱗癌[6.67%(1/15)]、大細(xì)胞癌[0.00%(0/4)]及其他癌[0.00%(0/3)]高(P0.05),同時臨床基線資料中女性EGFR基因突變檢出率[20.00%(4/20)]較男性[4.34%(1/23)]高(P0.05)。在臨床基線資料中年齡、吸煙史和TNM分期的EGFR基因突變檢出率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論新疆維吾爾族NSCLC患者EGFR基因突變與病理特征具一定相關(guān)性,臨床女性腺癌患者較多見。
[Abstract]:Objective to study the relationship between (NSCLC) epidermal growth factor receptor (EGFR) gene mutation and pathological features in Uygur non-small cell lung cancer (NSCLC). Methods from January 2003 to January 2014, 43 cases of NSCLC tissues from Xinjiang Uygur nationality treated by the second people's Hospital of Kashi region, Xinjiang, were retrospectively analyzed. All the pathological specimens were detected by EGFR gene mutation detection kit. The detection rate of EGFR gene mutation, the correlation between clinical symptom type and EGFR gene mutation, and the correlation between baseline data and EGFR gene mutation were observed. Results the mutation rate of EGFR gene was 11.63% (5 / 43). The deletion rate of exon 19 [80.00% (4 / 5)] was significantly higher than that of exon 21 L858R (20.00% (1 / 5) (P0.01). The detection rate of EGFR gene mutation in adenocarcinoma [19.05% (4 / 21)] was higher than that in squamous cell carcinoma [6.67% (1 / 15)]. Large cell carcinoma [0.00% (0 / 4)] and other cancers [0.00% (0 / 3)] were high (P0.05). At the same time, the detection rate of EGFR gene mutation in women [20.00% (4 / 20)] was higher than that in men [4.34% (1 / 23)] (P0.05). In clinical baseline data, there was no significant difference in the detection rate of EGFR gene mutation in age, smoking history and TNM stage (P0.05). Conclusion the mutation of EGFR gene in Xinjiang Uygur NSCLC patients is correlated with the pathological features.
【作者單位】： 新疆喀什地區(qū)第二人民醫(yī)院腫瘤科;復(fù)旦大學(xué)附屬腫瘤醫(yī)院腫瘤內(nèi)科;
【基金】：新疆維吾爾自治區(qū)科技支疆項目(2013911115)
【分類號】：R734.2

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