快速的致病基因分析方法
發(fā)布時間：2018-11-09 18:39
【摘要】：目前通過IBD定位研究致病基因首先需要檢測IBD片段,然后利用得到的IBD關(guān)系進(jìn)行關(guān)聯(lián)檢測來定位致病基因,但是尋找IBD片段需要較長時間。提出了一種新的算法FADG,通過分析IBS和IBD的關(guān)系找出候選IBD片段,然后定義評價函數(shù)分別對病例組和對照組進(jìn)行分析,差異最大的SNP位點(diǎn)就是致病位點(diǎn)。通過對GAW15提供的類風(fēng)濕關(guān)節(jié)炎模擬數(shù)據(jù)的五個主要的致病位點(diǎn)和GS生成的模擬數(shù)據(jù)進(jìn)行分析,實(shí)驗(yàn)結(jié)果與數(shù)據(jù)給定的致病位點(diǎn)一致;與已有的方法進(jìn)行對比表明該算法在能找到正確位點(diǎn)的基礎(chǔ)上效率較高;最后選擇了RA數(shù)據(jù)中兩條染色體分別進(jìn)行permutation測試,驗(yàn)證算法得到致病位點(diǎn)的可信度,進(jìn)一步排除所得結(jié)果假陽性的可能性。
[Abstract]:At present, it is necessary to detect the IBD fragment by IBD mapping, and then to locate the pathogenic gene by using the IBD relationship. However, it takes a long time to find the IBD fragment. A new algorithm, FADG, was proposed to identify candidate IBD fragments by analyzing the relationship between IBS and IBD. Then the evaluation function was defined to analyze the case group and the control group, respectively. The most different SNP locus was the pathogenicity site. Through the analysis of the five main pathogenic sites and the simulated data generated by GS from the simulated data of rheumatoid arthritis provided by GAW15, the experimental results are consistent with the given pathogenicity sites of the data. Compared with the existing methods, the algorithm is efficient on the basis of finding the correct sites. Finally, two chromosomes in RA data were selected for permutation test to verify the reliability of the algorithm to obtain the pathogenic sites, and further eliminate the possibility of false positive results.
【作者單位】： 天津科技大學(xué)計(jì)算機(jī)科學(xué)與信息工程學(xué)院;
【基金】：國家自然科學(xué)基金(No.31370075) 天津應(yīng)用基礎(chǔ)與前沿技術(shù)研究計(jì)劃(No.14JCQNJC00300)
【分類號】：R440
本文編號：2321245
[Abstract]:At present, it is necessary to detect the IBD fragment by IBD mapping, and then to locate the pathogenic gene by using the IBD relationship. However, it takes a long time to find the IBD fragment. A new algorithm, FADG, was proposed to identify candidate IBD fragments by analyzing the relationship between IBS and IBD. Then the evaluation function was defined to analyze the case group and the control group, respectively. The most different SNP locus was the pathogenicity site. Through the analysis of the five main pathogenic sites and the simulated data generated by GS from the simulated data of rheumatoid arthritis provided by GAW15, the experimental results are consistent with the given pathogenicity sites of the data. Compared with the existing methods, the algorithm is efficient on the basis of finding the correct sites. Finally, two chromosomes in RA data were selected for permutation test to verify the reliability of the algorithm to obtain the pathogenic sites, and further eliminate the possibility of false positive results.
【作者單位】： 天津科技大學(xué)計(jì)算機(jī)科學(xué)與信息工程學(xué)院;
【基金】：國家自然科學(xué)基金(No.31370075) 天津應(yīng)用基礎(chǔ)與前沿技術(shù)研究計(jì)劃(No.14JCQNJC00300)
【分類號】：R440
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