發(fā)布時(shí)間：2018-10-19 15:51

【摘要】：目的分析乳腺癌患者血親親屬對(duì)遺傳咨詢(xún)和基因檢測(cè)的了解和接受意愿。方法 992例乳腺癌患者的血親親屬配合完成調(diào)查表,根據(jù)年齡、家庭收入、學(xué)歷及腫瘤家族病史對(duì)數(shù)據(jù)進(jìn)行建表分類(lèi)及統(tǒng)計(jì)分析。結(jié)果參與完成調(diào)查的乳腺癌血親親屬大多數(shù)對(duì)遺傳咨詢(xún)和基因檢測(cè)不了解,但經(jīng)簡(jiǎn)單宣教,大多數(shù)受調(diào)者愿意接受遺傳咨詢(xún)并參與風(fēng)險(xiǎn)評(píng)估、篩查。79.8%的受調(diào)者愿意接受基因檢測(cè),62.3%的受調(diào)者愿意進(jìn)一步參與基因檢測(cè)相關(guān)流程。大多數(shù)受調(diào)者能接受價(jià)格便宜的基因初篩,僅37.9%的受調(diào)者能接受價(jià)格較高的基因檢測(cè)。假設(shè)基因檢測(cè)陽(yáng)性,大多數(shù)受調(diào)者愿意通過(guò)密切隨訪(fǎng)篩查進(jìn)行預(yù)防,31.3%的受調(diào)者愿意選擇預(yù)防性手術(shù)或藥物。盡管告知檢測(cè)結(jié)果保密,仍有32.9%的受調(diào)者擔(dān)心不利影響。結(jié)論大多數(shù)乳腺癌患者的血親親屬不了解但有明顯意愿接受遺傳咨詢(xún)和基因檢測(cè),對(duì)乳腺癌遺傳特點(diǎn)的誤解、費(fèi)用和受歧視的擔(dān)憂(yōu)是受調(diào)者接受遺傳咨詢(xún)、基因檢測(cè)和相關(guān)預(yù)防篩查的主要障礙。
[Abstract]:Objective to analyze the understanding and acceptance of genetic counseling and genetic detection among relatives of breast cancer patients. Methods 992 patients with breast cancer were investigated by blood relatives. The data were classified and statistically analyzed according to age, family income, educational background and family history. Results most of the relatives of breast cancer who completed the survey did not know about genetic counseling and genetic testing. However, after simple education, most of the respondents were willing to receive genetic advice and participate in risk assessment. 79.8% of the subjects were willing to be tested and 62.3% were willing to participate in the process of gene testing. Most of the subjects were able to accept the initial screening of cheap genes, while only 37.9% of the subjects were able to accept the higher price of genetic tests. Assuming positive gene test, most of the subjects were willing to undergo close follow-up screening for prevention, and 31.3% of the subjects preferred preventive surgery or medication. Although the results were kept confidential, 32.9% of the respondents were worried about the adverse effects. Conclusion most of the relatives of breast cancer patients do not understand but have a clear willingness to accept genetic counseling and genetic testing. The misunderstandings about genetic characteristics of breast cancer, the cost and the fear of discrimination is that the adjuster receives genetic counseling. Major barriers to genetic testing and related preventive screening.
【作者單位】： 同濟(jì)大學(xué)附屬第一婦嬰保健院乳腺外科;
【基金】：上海市衛(wèi)生局青年科研項(xiàng)目(20134Y094) 上海市科委西醫(yī)引導(dǎo)類(lèi)項(xiàng)目(15411964800)~~
【分類(lèi)號(hào)】：R737.9
，

本文編號(hào)：2281596