【摘要】：目的探討RGS20基因表達與Luminal型乳腺癌臨床病理特征的關(guān)系。方法利用癌癥基因組圖譜數(shù)據(jù)庫(TCGA數(shù)據(jù)庫)篩選出1023例乳腺癌病例和98例癌旁對照樣本,收集RGS20基因表達譜資料和臨床信息資料,分析RGS20基因表達與乳腺癌臨床病理特征的相關(guān)性及對預(yù)后的影響。結(jié)果 RGS20基因在不同乳腺癌分子分型中存在明顯的表達差異,其中在Luminal型乳腺癌為低表達,而在三陰性乳腺癌中為高表達。同時在Luminal型乳腺癌中,對RGS20基因表達水平與其臨床病理特征進行分析,發(fā)現(xiàn)RGS20基因表達水平與人種存在相關(guān)性(P0.05),其在黑種人中表達最高。進一步分析發(fā)現(xiàn)RGS20表達水平與ER受體水平存在密切相關(guān)(P0.001),ER受體陽性組其RGS20為低表達。結(jié)論 RGS20基因在Luminal型乳腺癌中表現(xiàn)為低表達,有別于其他類型的乳腺癌,且其表達水平與人種存在相關(guān)性,其中可能的機制是ER受體表達導(dǎo)致了RGS20基因的低表達,RGS20基因可能成為Luminal型乳腺癌的一個新的分子標(biāo)志物。
[Abstract]:Objective to investigate the relationship between RGS20 gene expression and clinicopathological features of Luminal type breast cancer. Methods 1023 breast cancer cases and 98 para-cancer control samples were screened by TCGA database. The data of RGS20 gene expression profile and clinical information were collected. To analyze the correlation between RGS20 gene expression and clinicopathological features of breast cancer and its influence on prognosis. Results there were significant differences in the expression of RGS20 gene in different molecular types of breast cancer, including low expression in Luminal type breast cancer and high expression in triple negative breast cancer. At the same time, in Luminal type breast cancer, the expression level of RGS20 gene and its clinicopathological characteristics were analyzed. It was found that the expression level of RGS20 gene was correlated with race (P0.05), and the highest expression level was found in black people. Further analysis showed that there was a close correlation between the expression of RGS20 and the level of ER receptor (P0. 001). The expression of RGS20 was low in the positive group of ER receptor (P0. 001). Conclusion the expression of RGS20 gene is low in Luminal type breast cancer, which is different from other types of breast cancer, and its expression level is correlated with race. The possible mechanism is that the expression of ER receptor leads to the low expression of RGS20 gene. RGS20 gene may become a new molecular marker of Luminal type breast cancer.
【作者單位】： 溫州醫(yī)科大學(xué)附屬第一醫(yī)院腫瘤外科;溫州醫(yī)科大學(xué)附屬第一醫(yī)院麻醉科;
【基金】：國家自然科學(xué)基金資助項目(81572580) 浙江省生物技術(shù)制藥工程重點實驗室項目(ZX-01-C2015051)
【分類號】：R737.9
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本文編號：2210203