本文選題：消化不良 + 胃促生長素　； 參考：《中華臨床醫(yī)師雜志(電子版)》2016年21期

【摘要】：目的探討胃促生長素(Ghrelin)基因Leu72Met位點多態(tài)性與體質(zhì)量減輕型功能性消化不良(FD-WL)的關(guān)聯(lián)性。方法選取2013年6月至2014年6月廣州市第一人民醫(yī)院南沙醫(yī)院消化�？崎T診94例FD-WL患者,64例健康對照者,共158例受試者。年齡為18~65周歲,病例組符合羅馬Ⅲ標準及發(fā)病前后12個月內(nèi)體質(zhì)量下降百分比≥5%。采用酶聯(lián)免疫印跡法(ELISA)檢測受試者空腹血清Ghrelin表達水平。采用聚合酶鏈式反應(yīng)以及限制性片段長度多態(tài)性(PCR-RFLP)的方法檢測Ghrelin基因Leu72Met位點多態(tài)性。采用χ2檢驗分析各組間基因型分布及等位基因頻率。采用多元逐步直線回歸分析基因型與臨床指標的相關(guān)性。結(jié)果在女性受試者中,攜帶Ghrelin基因Leu72Met AA+AC基因型的受試者在FD-WL組的比例顯著高于健康對照組(43.75%vs.37.21%,P=0.007,OR=2.79),且其體質(zhì)量和血清Ghrelin水平均明顯低于基因型CC組[體質(zhì)量:(55.62±9.76)kg vs.(58.02±9.65)kg,P0.05;Ghrelin:(4.87±4.65)ng/ml vs.(9.45±3.76)ng/ml,P0.05]。在男性受試者中,攜帶基因型AA+AC組的體質(zhì)量和BMI水平均明顯低于基因型CC組[體質(zhì)量:(65.28±9.56)kg vs.(69.58±9.39)kg,P0.05;BMI:(18.21±2.82)kg/m2 vs.(22.85±3.36)kg/m2,P0.05]。在全部受試者中,攜帶基因型AA+AC組的體質(zhì)量、BMI和血清Ghrelin水平均顯著低于基因型CC組[體質(zhì)量:(61.68±7.93)kg vs.(65.21±8.69)kg,P0.05;BMI:(18.85±3.51)kg/m2 vs.(21.38±2.72)kg/m2,P0.05;Ghrelin:(5.62±2.05)ng/ml vs.(9.32±1.6)ng/ml,P0.05]。結(jié)論 Ghrelin基因Leu72Met位點多態(tài)性與FD-WL密切相關(guān),為進一步闡明其發(fā)病機制提供依據(jù)。
[Abstract]:Objective to investigate the association between Leu72Met locus polymorphism of ghrelin gene and reduced body mass functional dyspepsia (FD-WL). Methods from June 2013 to June 2014, 94 FD-WL patients and 64 healthy controls were selected from Nansha Hospital of the first people's Hospital of Guangzhou, including 158 subjects. The age was 18 ~ 65 years old. The patient group was in accordance with the Rome 鈪，

本文編號：2118121