本文選題：XPD + XPC��； 參考：《中國腫瘤臨床》2017年08期

【摘要】：目的:探討DNA修復(fù)基因XPD rs13181(codon751A/C,Lys751Gln)、rs238406(codon156C/A,Arg156Arg)、XPC rs2279017(i11C/A)和XRCC4 rs3734091(codon247T/C,Ala247Ser)的單核苷酸多態(tài)性與結(jié)直腸癌易感性的關(guān)系。方法:采用Taq Man技術(shù)對2013年4月至2016年1月北京腫瘤醫(yī)院收治的338例結(jié)直腸癌患者(病例組)和315例健康者(對照組)進(jìn)行多態(tài)位點(diǎn)基因型的檢測。結(jié)果:XPD rs13181基因型GT和等位基因G增加個(gè)體結(jié)直腸癌的發(fā)病風(fēng)險(xiǎn)(GTTT,adjusted OR=1.69,95%CI:1.15~2.47,P=0.007;GT,adjusted OR=1.77,95%CI:1.19~2.64,P=0.005);XRCC4 rs3734091基因型GT和等位基因T增加個(gè)體結(jié)直腸癌的易感性(GTGG,adjusted OR=9.02,95%CI:5.61~14.50,P0.001;TG,adjusted OR=4.06,95%CI:2.49~6.61,P0.001);XPD rs13181和rs238406的單倍體型GT顯著降低結(jié)直腸癌的發(fā)病風(fēng)險(xiǎn)(adjusted OR=0.39,95%CI:0.18~0.85,P=0.018)。XPCrs2279017等位基因G和XRCC4 rs3734091等位基因T的聯(lián)合效應(yīng)(adjusted OR=28.43,95%CI:6.85~117.95,P0.001)以及XPD rs13181等位基因G和XRCC4 rs3734091等位基因T的聯(lián)合效應(yīng)(adjusted OR=10.24,95%CI:4.69~22.35,P0.001)顯著增加個(gè)體結(jié)直腸癌的易感性。結(jié)論:XPD rs13181和XRCC4 rs3734091位點(diǎn)的多態(tài)性與結(jié)直腸癌的易感性相關(guān)。
[Abstract]:Objective: to investigate the relationship between single nucleotide polymorphisms of DNA repair gene XPD rs13181codon751A / C rs238406 codon156C / Arg 156C / A) and XRCC4 rs3734091codon247T Cla247Sera). Methods: from April 2013 to January 2016, 338 colorectal cancer patients (case group) and 315 healthy persons (control group) were examined by Taq Man technique. 緇撴灉:XPD rs13181鍩哄洜鍨婫T鍜岀瓑浣嶅熀鍥燝澧炲姞涓綋緇撶洿鑲犵檶鐨勫彂鐥呴闄，

本文編號：2042598