本文選題：創(chuàng)造力 + COMT基因��； 參考：《山東師范大學(xué)》2017年碩士論文

【摘要】：創(chuàng)造力是社會(huì)發(fā)展的動(dòng)力,也是個(gè)體取得成功必須具備的能力。個(gè)體創(chuàng)造力受到遺傳和環(huán)境的共同作用,而且隨著分子遺傳學(xué)的發(fā)展,人們開始關(guān)注與創(chuàng)造力有關(guān)的基因及其與環(huán)境的交互作用。COMT基因是創(chuàng)造力重要的候選基因,父母教養(yǎng)方式是影響創(chuàng)造力的重要環(huán)境變量,二者交互作用可能對(duì)創(chuàng)造力有重要影響。此外,之前研究中單位點(diǎn)與環(huán)境交互作用的效果量普遍較小,而且對(duì)多位點(diǎn)聯(lián)合作用的忽視可能會(huì)限制研究者對(duì)個(gè)體生物易感性范圍的考察。由于某些基因效應(yīng)上潛在的性別差異,將涉及這些基因的分析分性別考察可能更合適。鑒于此,本研究擬考察COMT基因(多位點(diǎn)聯(lián)合作用)與父母教養(yǎng)方式的交互作用對(duì)創(chuàng)造力的影響及其性別差異。本研究的被試采用427名中國健康漢族的大學(xué)生,采用候選基因研究策略,對(duì)COMT基因上12個(gè)多態(tài)性位點(diǎn)進(jìn)行考察。首先采集被試靜脈血然后進(jìn)行DNA提取和基因分型,之后使用問卷調(diào)查法對(duì)個(gè)體的創(chuàng)造力及父母教養(yǎng)方式進(jìn)行測量。首先通過COMT基因單位點(diǎn)與父母教養(yǎng)方式交互作用的分析,發(fā)現(xiàn)與創(chuàng)造力有關(guān)的易感等位基因,之后以累加的方式(Pearson et al.,2014)計(jì)算出個(gè)體COMT基因多位點(diǎn)聯(lián)合的遺傳易感性指數(shù)(cumulative genetic susceptibility index,CGSI),從而考察CGSI與父母教養(yǎng)的交互作用對(duì)創(chuàng)造力水平差異的影響以及性別在其中可能的調(diào)節(jié)作用。本研究結(jié)論如下:(1)COMT基因(多位點(diǎn)聯(lián)合)與父母教養(yǎng)方式對(duì)創(chuàng)造力的交互作用顯著。表現(xiàn)為攜帶更多的易感等位基因的個(gè)體(CGSI1=3,CGSI2=4,5,CGSI3=2)在受到積極教養(yǎng)(高父/母權(quán)威或低母親放任)的影響時(shí)創(chuàng)造力水平更高,在受到消極教養(yǎng)(低父/母權(quán)威或高母親放任)的影響時(shí)創(chuàng)造力水平更低。(2)COMT基因與父母教養(yǎng)方式對(duì)創(chuàng)造力的交互作用具有性別差異。對(duì)女性而言,rs5993882、rs4646312、rs6269、rs4818、rs769224和母親權(quán)威型教養(yǎng)方式共同影響創(chuàng)造力(流暢性和獨(dú)創(chuàng)性)。對(duì)男性而言,rs6269、rs4818和父親權(quán)威型教養(yǎng)及母親放任型教養(yǎng)方式共同影響創(chuàng)造力(獨(dú)創(chuàng)性和靈活性)。(3)COMT基因與父母教養(yǎng)方式的交互作用的模式在不同位點(diǎn)上不同。CGSI(rs5993882、rs4646312和rs6269)與CGSI2(rs5993882、rs4646312、rs6269、rs4818和rs769224)同母親權(quán)威對(duì)女性創(chuàng)造力獨(dú)創(chuàng)性的交互作用符合不同易感模型;CGSI3(rs6269和rs4818)與母親放任對(duì)男性創(chuàng)造力獨(dú)創(chuàng)性的交互作用符合不同易感模型;CGSI3(rs6269和rs4818)與父親權(quán)威對(duì)男性創(chuàng)造力獨(dú)創(chuàng)性的交互作用符合素質(zhì)-壓力模型;CGSI3(rs6269和rs4818)與母親放任對(duì)男性創(chuàng)造力靈活性的交互作用符合優(yōu)勢敏感模型。
[Abstract]:Creativity is the driving force of social development and the ability of individuals to succeed. Individual creativity is influenced by heredity and environment, and with the development of molecular genetics, people begin to pay attention to the genes related to creativity and their interaction with environment. COMT gene is an important candidate gene for creativity. Parental rearing style is an important environmental variable affecting creativity, and the interaction between them may have an important impact on creativity. In addition, the effect of the interaction between unit point and environment in previous studies is generally small, and the neglect of the combination of multiple sites may limit the study of the range of individual biological susceptibility. Because of the potential gender differences in the effects of some genes, it may be more appropriate to examine the sex of the genes involved in the analysis. In view of this, this study intends to investigate the interaction between COMT gene and parental rearing style on creativity and its gender differences. Twelve polymorphic loci of COMT gene were studied in 427 healthy Chinese college students using candidate gene research strategy. First, the venous blood was collected, then DNA was extracted and genotyped, and then the creativity and parental rearing style were measured by questionnaire. First, by analyzing the interaction between COMT gene unit and parental rearing style, we found the susceptible alleles related to creativity. Then the cumulative method of Pearson et al.n2014) was used to calculate the genetic susceptibility index of individuals with multiple loci of COMT gene and the cumulative genetic susceptibility index, so as to investigate the influence of the interaction between CGSI and parental upbringing on the difference of creativity level and the possible regulation of gender among them. The results showed that the interaction of COMT gene (multiple loci combination) and parental rearing style on creativity was significant. Individuals with more susceptible alleles were found to have higher levels of creativity under the influence of active upbringing (high parent authority or low maternal indulgence). Under the influence of negative parenting (low parental authority or high maternal laissez-faire), the creativity level was lower. The interaction between COMT gene and parental rearing style had gender differences. For women, rs5993882 / rs4646312 / rs6269 / rs4818 / rs769224 and mother's authoritative upbringing influence creativity (fluency and originality). For men, rs6269rs4818 and father's authoritative parenting and mother's laissez-faire parenting patterns affect creativity (the patterns of interaction between the original and flexible COMT gene and parental rearing styles vary at different loci.) and CGSI2rs5993882 rs4646312 and rs6269) and CGSI2rs5993882rs463269rs4818 The interaction with mother authority on female creativity originality in accordance with different susceptibility models: CGSI3rs6269 and rs4818) and mother's laissez-faire interaction on male creativity originality in accordance with different susceptibility models CGSI3rs6269 and rs4818) and paternal authority on men The interaction of creativity originality was consistent with the quality-stress model CGSI3Rs6269 and rs4818) and the interaction of mother's laissez-faire to male creativity flexibility was in accordance with the advantage sensitive model.
【學(xué)位授予單位】：山東師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：B844.2;G78

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