本文選題：胰腺炎 + 腫瘤壞死因子-α��； 參考：《重慶醫(yī)學》2017年27期

【摘要】：目的探討急性胰腺炎患者腫瘤壞死因子-α(TNF-α)基因多態(tài)性與患者病情嚴重程度及臨床預后的相關(guān)性。方法選取山東省醫(yī)學高等專科學校附屬醫(yī)院2015年6月至2016年6月確診的325例急性胰腺炎患者,采集外周血檢測TNF-α基因多態(tài)性,并用Balthazer CT嚴重指數(shù)(CTSI)評分和急性生理與慢性健康評分(APACHEⅡ)評價患者胰腺炎病情,根據(jù)患者APACHEⅡ評分進行分組,7分的患者為觀察組,7分的患者為對照組,對比兩組患者CTSI評分、TNF-α基因表達情況,并采用Logistic回歸模型分析TNF-α基因多態(tài)性與急性胰腺炎預后的關(guān)系。結(jié)果觀察組96例患者A/A基因型為68例,占70.1%,CTSI評分為(8.3±0.4)分,明顯高于對照組患者,差異有統(tǒng)計學意義(P0.05),Logistic回歸分析結(jié)果提示APACHEⅡ評分上升3分(P=0.016)、TNF-α基因rs1800629位點基因型為A/A(P=0.04)、CTSI評分上升2分(P=0.012)均是患者預后不良的獨立危險因素。結(jié)論 TNF-α基因多態(tài)性及CTSI評分與急性胰腺炎病情嚴重程度及臨床預后密切相關(guān)。
[Abstract]:Objective to investigate the relationship between tumor necrosis factor- 偽 (TNF- 偽) gene polymorphism and severity and clinical prognosis in patients with acute pancreatitis. Methods from June 2015 to June 2016, 325 patients with acute pancreatitis were selected from affiliated Hospital of Shandong Medical College, and peripheral blood samples were collected to detect the polymorphism of TNF- 偽 gene. The severity index of Balthazer CT and acute physiological and chronic health score (Apache 鈪，

本文編號：1911654