本文選題：癲癇 + 拉莫三嗪　； 參考：《安徽醫(yī)科大學(xué)》2016年碩士論文

【摘要】：目的近年來在國(guó)內(nèi)外人群中的研究表明,HLA-A*3001,HLA-A*3101,HLA-B*1502,HLA-B*38,HLA-B*5801等位基因可能與拉莫三嗪所致藥疹存在相關(guān)性,而在新疆維吾爾族人群中尚沒有該類研究的報(bào)道,因此本研究旨在探討HLA-A*3001,HLA-A*3101,HLA-B*1502,HLA-B*38,HLA-B*5801等位基因與新疆維吾爾族癲癇患者中拉莫三嗪(LTG)所致藥疹的關(guān)聯(lián)性。方法在新疆地區(qū)28例使用LTG的維吾爾族癲癇患者(其中10例出現(xiàn)斑丘疹(M PE),18例未出現(xiàn)皮膚不良反應(yīng)),以及30例維吾爾族健康受試者中,采用序列特異性引物-聚合酶鏈?zhǔn)椒磻?yīng)技術(shù)(PCR-SSP),進(jìn)行HLA-A*3001,HLA-A*3101,HLA-B*1502,HLA-B*38,HLA-B*5801等位基因篩選,并采用SPSS 19.0統(tǒng)計(jì)學(xué)軟件進(jìn)行統(tǒng)計(jì)學(xué)分析,通過卡方檢驗(yàn)比較各組間HLA基因頻率的差異性,通過t檢驗(yàn)比較各組間的計(jì)量資料,P0.05代表組間具有顯著性差異,并計(jì)算比值比(Od ds Ratio,OR)及其95%置信區(qū)間(Confidence Interval,CI),作為HLA基因與拉莫三嗪所致皮膚不良反應(yīng)相關(guān)性的評(píng)價(jià)指標(biāo)。結(jié)果在LTG-MPE和LTG耐受組之間,HLA-A*3001(P=0.936,OR=2,95%CI 0.236-16.928),HLA-A*3101(P=0.585,OR=4.25,95%CI 0.334-54.066),HLA-B*1502(P=0.875,OR=0.818,95%CI 0.066-10.117),HLA-B*38(P=0.875,OR=0.818,95%CI 0.066-10.117),HLA-B*5801(P=0.585,OR=4.25,95%CI 0.334-54.066)等位基因陽(yáng)性率不存在顯著性差異;在LTG-MPE和健康受試者之間,HLA-A*3001(P=0.543,OR=3.5,95%CI 0.424-28.915),HLA-A*3101(P=0.783,OR=2.25,95%CI 0.318-15.901),HLA-B*1502(P=0.811,OR=1.364,95%CI 0.112-16.577),HLAB*38(P=0.893,OR=0.491,95%CI 0.051-4.698),HLA-B*5801(P=0.298,OR=7.25,95%CI 0.581-90.545)等位基因陽(yáng)性率也不存在顯著性差異。結(jié)論在新疆維吾爾族癲癇患者中,HLA-A*3001,HLA-A*3101,HLA-B*1502,H LA-B*38,HLA-B*5801等位基因與LTG-MPE不存在顯著相關(guān)性,但是由于樣本量較少,統(tǒng)計(jì)學(xué)意義有限,因此仍需大樣本研究進(jìn)一步證實(shí)。
[Abstract]:Objective in recent years, studies in domestic and foreign population indicated that the allele of HLA-AHA-3101T / HLA-B3101Hla / B ~ (3102N) / HLA-B ~ (5801) allele may be associated with drug rash induced by lamotrigine, but there is no report of this kind of allele in Xinjiang Uygur nationality population (Uygur), and there is no report of this kind of allele in Xinjiang Uygur population. The aim of this study was to investigate the association between HLA-A3101T alleles and drug rash induced by lamotriazine (LTG) in Xinjiang Uygur patients with epilepsy. Methods among 28 Uygur epilepsy patients who were treated with LTG in Xinjiang area (10 cases with MPEP, 18 cases with no adverse skin reaction) and 30 healthy Uygur subjects were included in this study. Sequence specific primer polymerase chain reaction (PCR-SSPN) technique was used to screen the HLA-Bn5801 alleles of HLA-AHA-3101T, and the SPSS 19.0 statistical software was used to analyze the frequency of HLA gene. The frequency of HLA gene in each group was compared by chi-square test. T test was used to compare the significant difference between the two groups (P0.05), and to calculate the ratio of Ods Ratioor) and 95% confidence interval (CI), which was used as an index to evaluate the correlation between HLA gene and adverse skin reaction induced by lamotrigine. 緇撴灉鍦↙TG-MPE鍜孡TG鑰愬彈緇勪箣闂，

本文編號(hào)：1909141